Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside

Run Wang; Todd R. Higuera; Suresh C. Sikka; Robert K. Minkes; John A. Bellan; Philip J. Kadowitz; Floyd R. Domer; Wayne J. Hellstrom

doi:10.1007/BF00295198

Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside

Run Wang, Todd R. Higuera, Suresh C. Sikka, Robert K. Minkes, John A. Bellan, Philip J. Kadowitz, Floyd R. Domer, Wayne J. Hellstrom

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E₁, and phentolamine was studied in 22 adult cats. The maximal erectile response (intracavernous pressure, penile length, and rigidity) was produced by intracavernous injection of a combination of 1.65 mg papaverine, 0.5μg PGE₁, and 25μg phentolamine. This combination was considered as "control" in order to compare the effect of other agents. VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5μg VIP or 10μg SNP. The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P<0.01). Epinephrine (30μg) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P<0.05). This study supports the use of an in vivo feline model for the evaluation of vasoactive agents and demonstrates that the intracavernous injection of either VIP or SNP can induce penile erection in the adult cat.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	Urological Research
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/BF00295198
State	Published - Jan 1993
Externally published	Yes

Keywords

Nitroprusside
Penile erection, feline model
VIP

ASJC Scopus subject areas

Urology

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10.1007/BF00295198

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title = "Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside",

abstract = "The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats. The maximal erectile response (intracavernous pressure, penile length, and rigidity) was produced by intracavernous injection of a combination of 1.65 mg papaverine, 0.5μg PGE1, and 25μg phentolamine. This combination was considered as {"}control{"} in order to compare the effect of other agents. VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5μg VIP or 10μg SNP. The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P<0.01). Epinephrine (30μg) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P<0.05). This study supports the use of an in vivo feline model for the evaluation of vasoactive agents and demonstrates that the intracavernous injection of either VIP or SNP can induce penile erection in the adult cat.",

keywords = "Nitroprusside, Penile erection, feline model, VIP",

author = "Run Wang and Higuera, {Todd R.} and Sikka, {Suresh C.} and Minkes, {Robert K.} and Bellan, {John A.} and Kadowitz, {Philip J.} and Domer, {Floyd R.} and Hellstrom, {Wayne J.}",

year = "1993",

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doi = "10.1007/BF00295198",

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AU - Wang, Run

AU - Higuera, Todd R.

AU - Sikka, Suresh C.

AU - Minkes, Robert K.

AU - Bellan, John A.

AU - Kadowitz, Philip J.

AU - Domer, Floyd R.

AU - Hellstrom, Wayne J.

PY - 1993/1

Y1 - 1993/1

N2 - The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats. The maximal erectile response (intracavernous pressure, penile length, and rigidity) was produced by intracavernous injection of a combination of 1.65 mg papaverine, 0.5μg PGE1, and 25μg phentolamine. This combination was considered as "control" in order to compare the effect of other agents. VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5μg VIP or 10μg SNP. The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P<0.01). Epinephrine (30μg) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P<0.05). This study supports the use of an in vivo feline model for the evaluation of vasoactive agents and demonstrates that the intracavernous injection of either VIP or SNP can induce penile erection in the adult cat.

AB - The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats. The maximal erectile response (intracavernous pressure, penile length, and rigidity) was produced by intracavernous injection of a combination of 1.65 mg papaverine, 0.5μg PGE1, and 25μg phentolamine. This combination was considered as "control" in order to compare the effect of other agents. VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5μg VIP or 10μg SNP. The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P<0.01). Epinephrine (30μg) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P<0.05). This study supports the use of an in vivo feline model for the evaluation of vasoactive agents and demonstrates that the intracavernous injection of either VIP or SNP can induce penile erection in the adult cat.

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Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside

Abstract

Keywords

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