TY - JOUR
T1 - Patrilocal* * patrilocal
T2 - taking the bride to the husband's home village cell-cell interactions: sevenless captures its bride
AU - Kramer, Helmut
PY - 1993/4
Y1 - 1993/4
N2 - Development of the R7 neuron in the compound eye of Drosophila requires an inductive interaction between the R8 photoreceptor cell and the bipotential R7 precursor cell. Two transmembrane proteins mediate this induction: sevenless (sev), a receptor tyrosine kinase expressed on the apical surface of the R7 precursor cell, and its ligand, the bride of sevenless protein (boss) on the apical membrane of the R8 neuron. The boss protein, with its large extracellular domain and seven transmembrane segments, is an unusual ligand for a receptor tyrosine kinase, and its internalization into the R7 cell following interaction with sev is particularly intriguing.
AB - Development of the R7 neuron in the compound eye of Drosophila requires an inductive interaction between the R8 photoreceptor cell and the bipotential R7 precursor cell. Two transmembrane proteins mediate this induction: sevenless (sev), a receptor tyrosine kinase expressed on the apical surface of the R7 precursor cell, and its ligand, the bride of sevenless protein (boss) on the apical membrane of the R8 neuron. The boss protein, with its large extracellular domain and seven transmembrane segments, is an unusual ligand for a receptor tyrosine kinase, and its internalization into the R7 cell following interaction with sev is particularly intriguing.
UR - http://www.scopus.com/inward/record.url?scp=0027479789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027479789&partnerID=8YFLogxK
U2 - 10.1016/0962-8924(93)90165-W
DO - 10.1016/0962-8924(93)90165-W
M3 - Article
C2 - 14731763
AN - SCOPUS:0027479789
SN - 0962-8924
VL - 3
SP - 103
EP - 105
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 4
ER -