TY - JOUR
T1 - Patient Demographics Influencing Vestibular Schwannoma Size and Initial Management Plans
AU - Ostler, Brian
AU - Killeen, Daniel E.
AU - Reisch, Joan
AU - Barnett, Samuel
AU - Kutz, J. Walter
AU - Isaacson, Brandon
AU - Hunter, Jacob Boston
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/4
Y1 - 2020/4
N2 - Objective: To explore patient demographics as to predicting vestibular schwannoma (VS) size and treatment plan within a single institution. Methods: Using a large tertiary referral skull base center database, all patients with sporadic VS who presented to the center between 2009 and 2018 were reviewed. Results: A total of 816 patients with VS over 18 years of age were included. The median age was 56.8 years (range: 18.6–90.9 years). The median tumor diameter at diagnosis was 11.9 mm (range: 0.6–51.1 mm). With multivariate analysis, older age was associated with decreased tumor size (0.23 mm, 95% confidence interval [CI]: 0.17–0.29), whereas married patients had larger tumors (2.5 mm, 95% CI: 0.92–4.09). When comparing observation, radiation, or surgery, older patients are more likely to pursue observation as compared with surgery and radiation (odds ratio [OR]: 1.08, 95% CI: 1.06–1.10 and OR: 1.20, 95% CI: 1.08–1.33), respectively. Married patients were less likely to pursue observation as compared with surgery (OR: 0.49, 95% CI: 0.29–0.82). Each additional mile a patient lives farther from the center increases his or her odds of pursuing treatment (OR: 1.002, 95% CI: 1.001–1.003). Conclusions: Older age is associated with smaller tumors, whereas married patients have larger tumors at diagnosis as compared with nonmarried patients. Furthermore, married patients are more likely to pursue treatment, specifically surgery, as compared with nonmarried patients, whereas patients who live farther from the center are more likely to pursue treatment.
AB - Objective: To explore patient demographics as to predicting vestibular schwannoma (VS) size and treatment plan within a single institution. Methods: Using a large tertiary referral skull base center database, all patients with sporadic VS who presented to the center between 2009 and 2018 were reviewed. Results: A total of 816 patients with VS over 18 years of age were included. The median age was 56.8 years (range: 18.6–90.9 years). The median tumor diameter at diagnosis was 11.9 mm (range: 0.6–51.1 mm). With multivariate analysis, older age was associated with decreased tumor size (0.23 mm, 95% confidence interval [CI]: 0.17–0.29), whereas married patients had larger tumors (2.5 mm, 95% CI: 0.92–4.09). When comparing observation, radiation, or surgery, older patients are more likely to pursue observation as compared with surgery and radiation (odds ratio [OR]: 1.08, 95% CI: 1.06–1.10 and OR: 1.20, 95% CI: 1.08–1.33), respectively. Married patients were less likely to pursue observation as compared with surgery (OR: 0.49, 95% CI: 0.29–0.82). Each additional mile a patient lives farther from the center increases his or her odds of pursuing treatment (OR: 1.002, 95% CI: 1.001–1.003). Conclusions: Older age is associated with smaller tumors, whereas married patients have larger tumors at diagnosis as compared with nonmarried patients. Furthermore, married patients are more likely to pursue treatment, specifically surgery, as compared with nonmarried patients, whereas patients who live farther from the center are more likely to pursue treatment.
KW - Acoustic neuroma
KW - Demography
KW - Marriage
KW - Race
KW - Skull base
KW - Treatment outcome
KW - Vestibular schwannoma
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U2 - 10.1016/j.wneu.2020.01.019
DO - 10.1016/j.wneu.2020.01.019
M3 - Article
C2 - 31931234
AN - SCOPUS:85079063009
SN - 1878-8750
VL - 136
SP - e440-e446
JO - World neurosurgery
JF - World neurosurgery
ER -