Patient and other stakeholder engagement in patient-centered outcomes research institute funded studies of patients with kidney diseases

Daniel Cukor, Lewis M. Cohen, Elizabeth L. Cope, Nasrollah Ghahramani, S. Susan Hedayati, Denise M. Hynes, Vallabh O. Shah, Francesca Tentori, Mark Unruh, Jeanette Bobelu, Scott Cohen, Laura M. Dember, Thomas Faber, Michael J. Fischer, Rani Gallardo, Michael J. Germain, Donica Ghahate, Nancy Grote, Lori Hartwell, Patrick HeagertyPaul L. Kimmel, Nancy Kutner, Susan Lawson, Lisa Marr, Robert G. Nelson, Anna C. Porter, Phillip Sandy, Bruce B. Struminger, Lalita Subramanian, Steve Weisbord, Bessie Young, Rajnish Mehrotra

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Including target populations in the design and implementation of research trials has been one response to the growing health disparities endemic to our health care system, as well as an aid to study generalizability. One type of community-based participatory research is “Patient Centered-Research”, in which patient perspectives on the germane research questions and methodologies are incorporated into the study. The Patient-Centered Outcomes Research Institute (PCORI) has mandated that meaningful patient and stakeholder engagement be incorporated into all applications. As of March 2015, PCORI funded seven clinically-focused studies of patients with kidney disease. The goal of this paper is to synthesize the experiences of these studies to gain an understanding of how meaningful patient and stakeholder engagement can occur in clinical research of kidney diseases, and what the key barriers are to its implementation. Our collective experience suggests that successful implementation of a patient- and stakeholder-engaged research paradigm involves: (1) defining the roles and process for the incorporation of input; (2) identifying the particular patients and other stakeholders; (3) engaging patients and other stakeholders so they appreciate the value of their own participation and have personal investment in the research process; and (4) overcoming barriers and challenges that arise and threaten the productivity of the collaboration. It is our hope that the experiences of these studies will further interest and capacity for incorporating patient and stakeholder perspectives in research of kidney diseases.

Original languageEnglish (US)
Pages (from-to)1703-1712
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Issue number9
StatePublished - 2016


  • Chronic kidney disease
  • Clinical nephrology
  • Community-Based Participatory Research
  • Depression
  • Diabetic nephropathy
  • Dialysis
  • End-stage renal disease
  • Humans
  • Kidney disease
  • Nephrotic syndrome
  • Patient Outcome Assessment
  • Randomized controlled trials

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation


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