Pathophysiology of Pelvic Organ Prolapse

R. Ann Word, Sujatha Pathi, Joseph I. Schaffer

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


The pathophysiology of pelvic organ prolapse is believed to be multifactorial. Several risk factors, such as childbirth and aging, have been identified. Suspected aberrations in the structure and function of the connective tissue, muscles, and nerves of the pelvic floor are still under investigation. In this article, the cellular, biochemical, and molecular basis of pelvic organ prolapse is discussed with a focus on the new theory of elastinopathy as an etiology of prolapse.

Original languageEnglish (US)
Pages (from-to)521-539
Number of pages19
JournalObstetrics and gynecology clinics of North America
Issue number3
StatePublished - Sep 2009


  • Collagen
  • Elastic fibers
  • Matrix metalloprotease
  • Prolapse
  • Protease
  • Vagina

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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