Pathophysiology of Pelvic Organ Prolapse

R. Ann Word; Sujatha Pathi; Joseph I. Schaffer

doi:10.1016/j.ogc.2009.09.001

Pathophysiology of Pelvic Organ Prolapse

R. Ann Word, Sujatha Pathi, Joseph I. Schaffer

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

The pathophysiology of pelvic organ prolapse is believed to be multifactorial. Several risk factors, such as childbirth and aging, have been identified. Suspected aberrations in the structure and function of the connective tissue, muscles, and nerves of the pelvic floor are still under investigation. In this article, the cellular, biochemical, and molecular basis of pelvic organ prolapse is discussed with a focus on the new theory of elastinopathy as an etiology of prolapse.

Original language	English (US)
Pages (from-to)	521-539
Number of pages	19
Journal	Obstetrics and gynecology clinics of North America
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.ogc.2009.09.001
State	Published - Sep 2009

Keywords

Collagen
Elastic fibers
Matrix metalloprotease
Prolapse
Protease
Vagina

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ogc.2009.09.001

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abstract = "The pathophysiology of pelvic organ prolapse is believed to be multifactorial. Several risk factors, such as childbirth and aging, have been identified. Suspected aberrations in the structure and function of the connective tissue, muscles, and nerves of the pelvic floor are still under investigation. In this article, the cellular, biochemical, and molecular basis of pelvic organ prolapse is discussed with a focus on the new theory of elastinopathy as an etiology of prolapse.",

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AU - Pathi, Sujatha

AU - Schaffer, Joseph I.

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AB - The pathophysiology of pelvic organ prolapse is believed to be multifactorial. Several risk factors, such as childbirth and aging, have been identified. Suspected aberrations in the structure and function of the connective tissue, muscles, and nerves of the pelvic floor are still under investigation. In this article, the cellular, biochemical, and molecular basis of pelvic organ prolapse is discussed with a focus on the new theory of elastinopathy as an etiology of prolapse.

KW - Collagen

KW - Elastic fibers

KW - Matrix metalloprotease

KW - Prolapse

KW - Protease

KW - Vagina

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ER -

Pathophysiology of Pelvic Organ Prolapse

Abstract

Keywords

ASJC Scopus subject areas

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