TY - JOUR
T1 - Pathophysiology and progression of nasal septal perforation
AU - Lanier, Bobby
AU - Kai, Guan
AU - Marple, Bradley
AU - Wall, G. Michael
N1 - Funding Information:
This feature is supported in part by an educational grant from AstraZeneca LP
PY - 2007/12
Y1 - 2007/12
N2 - Objective: To review the prevalence, causes, and treatments of nasal septal perforation (NSP). Data Sources: A literature search was conducted in MEDLINE to identify peer-reviewed articles related to NSP using the keywords nasal septal perforation and septal perforation for articles published between January 1, 1969, and December 31, 2006, and references cited therein. Study Selection: Articles were selected based on their direct applicability to the subject matter. Results: Causes of NSPs include piercings, exposure to industrial chemicals, illicit drug use, intranasal steroid use, surgical trauma, bilateral cautery, and possibly improper use of nasal applicators. Prevalence is poorly reported. Mechanisms of substance-induced NSP formation are not understood. Progression from epistaxis to ulceration to NSP could not be substantiated by the literature. Conclusion: Depending on the patient, NSP may be viewed as desirable (nose rings), problematic (whistling, congestion), or inconsequential. Understanding the pathogenesis of NSP is important for the practicing physician required to make decisions about whether to recommend surgical correction or medical treatment. Although the etiology of NSP is overwhelmingly iatrogenic, there is an association with a number of medical diseases in addition to use of illicit drugs and/or prescription nasal sprays.
AB - Objective: To review the prevalence, causes, and treatments of nasal septal perforation (NSP). Data Sources: A literature search was conducted in MEDLINE to identify peer-reviewed articles related to NSP using the keywords nasal septal perforation and septal perforation for articles published between January 1, 1969, and December 31, 2006, and references cited therein. Study Selection: Articles were selected based on their direct applicability to the subject matter. Results: Causes of NSPs include piercings, exposure to industrial chemicals, illicit drug use, intranasal steroid use, surgical trauma, bilateral cautery, and possibly improper use of nasal applicators. Prevalence is poorly reported. Mechanisms of substance-induced NSP formation are not understood. Progression from epistaxis to ulceration to NSP could not be substantiated by the literature. Conclusion: Depending on the patient, NSP may be viewed as desirable (nose rings), problematic (whistling, congestion), or inconsequential. Understanding the pathogenesis of NSP is important for the practicing physician required to make decisions about whether to recommend surgical correction or medical treatment. Although the etiology of NSP is overwhelmingly iatrogenic, there is an association with a number of medical diseases in addition to use of illicit drugs and/or prescription nasal sprays.
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U2 - 10.1016/S1081-1206(10)60373-0
DO - 10.1016/S1081-1206(10)60373-0
M3 - Review article
C2 - 18219827
AN - SCOPUS:37349055098
SN - 1081-1206
VL - 99
SP - 473
EP - 480
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 6
ER -