Abstract
Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.
Original language | English (US) |
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Pages (from-to) | 388-400 |
Number of pages | 13 |
Journal | Circulation |
Volume | 128 |
Issue number | 4 |
DOIs | |
State | Published - Jul 23 2013 |
Keywords
- cardiac electrophysiology
- fibrosis
- inflammation
- stem cells
- ventricular remodeling
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)