TY - JOUR
T1 - Paternal age as a risk factor for Down syndrome
AU - De Michelena, M. I.
AU - Burstein, E.
AU - Lama, J. R.
AU - Vasquez, J. C.
PY - 1993
Y1 - 1993
N2 - Although the effect of maternal age as a risk factor for Down syndrome (DS) is well known, the role of paternal age in the cause of DS has not been clearly established. To investigate this phenomenon we conducted a case- control study between July 1989 and February 1990. The cases were 318 children and teenagers with DS studied at the Specialized Educational Institutions of Lima City, Peru. They were paired with 1,196 control individuals that were selected from the birth records of 2 general hospitals of the city. For each case we tried to obtain 4 controls, paired by their date of birth, sex, and maternal age. The means of paternal age in the 2 groups were compared, first globally and then by groups of maternal age (<21 years, 21-29 years, 30-34 years, 35-39 years and >39 years). None of the comparisons gave a statistically significant difference between the 2 groups, using either the Student t-test or the Mann-Whitney U-test. The results obtained in this study give no evidence that paternal age can be considered a risk factor for the conception of a child with DS.
AB - Although the effect of maternal age as a risk factor for Down syndrome (DS) is well known, the role of paternal age in the cause of DS has not been clearly established. To investigate this phenomenon we conducted a case- control study between July 1989 and February 1990. The cases were 318 children and teenagers with DS studied at the Specialized Educational Institutions of Lima City, Peru. They were paired with 1,196 control individuals that were selected from the birth records of 2 general hospitals of the city. For each case we tried to obtain 4 controls, paired by their date of birth, sex, and maternal age. The means of paternal age in the 2 groups were compared, first globally and then by groups of maternal age (<21 years, 21-29 years, 30-34 years, 35-39 years and >39 years). None of the comparisons gave a statistically significant difference between the 2 groups, using either the Student t-test or the Mann-Whitney U-test. The results obtained in this study give no evidence that paternal age can be considered a risk factor for the conception of a child with DS.
KW - nondisjunction
KW - role of paternal age
KW - trisomy 21
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U2 - 10.1002/ajmg.1320450605
DO - 10.1002/ajmg.1320450605
M3 - Article
C2 - 8456845
AN - SCOPUS:0027478965
SN - 0148-7299
VL - 45
SP - 679
EP - 682
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
IS - 6
ER -