PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS

JeffreyD Thorley; RandallK Holmes; J. Martin Kaplan; GeorgeH Mccracken; JayP Sanford

doi:10.1016/S0140-6736(75)91757-2

PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS

JeffreyD Thorley, RandallK Holmes, J. Martin Kaplan, GeorgeH Mccracken, JayP Sanford

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (C.S.F.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.F. of infants. These observations suggest that an important source of immunoglobulins in C.S.F. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with C.S.F.

Original language	English (US)
Pages (from-to)	651-653
Number of pages	3
Journal	The Lancet
Volume	305
Issue number	7908
DOIs	https://doi.org/10.1016/S0140-6736(75)91757-2
State	Published - Mar 22 1975

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(75)91757-2

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title = "PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS",

abstract = "The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (C.S.F.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.F. of infants. These observations suggest that an important source of immunoglobulins in C.S.F. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with C.S.F.",

author = "JeffreyD Thorley and RandallK Holmes and {Martin Kaplan}, J. and GeorgeH Mccracken and JayP Sanford",

note = "Funding Information: and 5 T01 Al 00337 and by research grant 5 R22 Al 11478 from the National Institutes of Health, and by the John A.",

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T1 - PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS

AU - Thorley, JeffreyD

AU - Holmes, RandallK

AU - Martin Kaplan, J.

AU - Mccracken, GeorgeH

AU - Sanford, JayP

N1 - Funding Information: and 5 T01 Al 00337 and by research grant 5 R22 Al 11478 from the National Institutes of Health, and by the John A.

PY - 1975/3/22

Y1 - 1975/3/22

N2 - The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (C.S.F.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.F. of infants. These observations suggest that an important source of immunoglobulins in C.S.F. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with C.S.F.

AB - The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (C.S.F.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.F. of infants. These observations suggest that an important source of immunoglobulins in C.S.F. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with C.S.F.

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PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS

Abstract

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