@article{aafb3fef7cb2457c80500dace1016cba,
title = "Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy",
abstract = "Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic leptin sensitivity and leads to reduced food intake, increased energy expenditure, and improved insulin sensitivity. Thus, strategies aimed at partially reducing circulating leptin may represent a promising approach for the treatment of obesity and diabetes.",
keywords = "diabetes, hypothalamus, leptin, leptin resistance, obesity",
author = "Shangang Zhao and Yi Zhu and Schultz, {Robbie D.} and Na Li and Zhenyan He and Zhuzhen Zhang and Alexandre Caron and Qingzhang Zhu and Kai Sun and Wei Xiong and Hui Deng and Jia Sun and Yingfeng Deng and Min Kim and Lee, {Charlotte E.} and Ruth Gordillo and Tiemin Liu and Odle, {Angela K.} and Childs, {Gwen V.} and Ningyan Zhang and Kusminski, {Christine M.} and Elmquist, {Joel K.} and Williams, {Kevin W.} and Zhiqiang An and Scherer, {Philipp E.}",
note = "Funding Information: We kindly thank J. Song and S. Connell for technical assistance, in addition to the rest of the Scherer and Elmquist laboratories for helpful discussions. We would also like to thank Bob Hammer and the UTSW Transgenic Core Facility for the generation of mouse models, as well as the UTSW Metabolic Core Facility. This work was supported by US National Institutes of Health grants R01-DK55758 , R01-DK099110 , RC2-DK118620 , and P01DK088761 (to P.E.S.), and a Robert A. Welch Foundation grant to Z.A. ( AU-0042-20030616 ). This work was also supported by grants to J.K.E. (US National Institutes of Health grant RO1-DK118725 ) and K.W.W. (US National Institutes of Health grants R01-DK100699 and R01 DK119169). S.Z. was supported by a Post-Doctoral Fellowship from Fonds de Recherche Sante Quebec (FRQS) ; Y.Z. was supported by NIH grant K99-DK114898 . A.C. was a Canadian Institutes of Health Research (CIHR) Banting fellow and supported by the NIH ( K99 DK120894 ) G.V.C. is supported by US National Institutes of Health grants R03-HD059066 and R01-HD059056 and Core Facilities in the Center for Translational Neuroscience NIH NIGMS P20-GM103425 . Funding Information: We kindly thank J. Song and S. Connell for technical assistance, in addition to the rest of the Scherer and Elmquist laboratories for helpful discussions. We would also like to thank Bob Hammer and the UTSW Transgenic Core Facility for the generation of mouse models, as well as the UTSW Metabolic Core Facility. This work was supported by US National Institutes of Health grants R01-DK55758, R01-DK099110, RC2-DK118620, and P01DK088761 (to P.E.S.), and a Robert A. Welch Foundation grant to Z.A. (AU-0042-20030616). This work was also supported by grants to J.K.E. (US National Institutes of Health grant RO1-DK118725) and K.W.W. (US National Institutes of Health grants R01-DK100699 and R01 DK119169). S.Z. was supported by a Post-Doctoral Fellowship from Fonds de Recherche Sante Quebec (FRQS); Y.Z. was supported by NIH grant K99-DK114898. A.C. was a Canadian Institutes of Health Research (CIHR) Banting fellow and supported by the NIH (K99 DK120894) G.V.C. is supported by US National Institutes of Health grants R03-HD059066 and R01-HD059056 and Core Facilities in the Center for Translational Neuroscience NIH NIGMS P20-GM103425. S.Z. Y.Z. N.L. Z.Z. Q.Z. Y.D. R.G. C.E.L. and C.M.K. conducted most of the experiments. H.Y. and K.W.W. conducted patch-clamp study and analyzed the results. K.S. generated the Cas9-based mouse model. W.X. produced different versions (in mouse and human chimera and mouse antibodies for in vitro and in vivo assays). H.D. converted the scFv fragments into full IgGs. M.K. generated TRE-leptin mice. R.D.S. constructed the phage library and isolated the leptin antibodies from the library. G.V.C. and A.K.O. kindly generated and provided the leptin-floxed mice. N.Z. Z.A. R.D.S. W.X. and H.D. generated the leptin antibodies. N.Z. and Z.A. were involved in experimental designs for antibody studies and data interpretation. A.C. J.S. and T.L. helped with MBH isolation and discussion. S.Z. and P.E.S. wrote the manuscript. C.M.K. revised the manuscript. P.E.S. and J.K.E. were involved in experimental design, experiments, data analysis, and the interpretation of data. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "1",
doi = "10.1016/j.cmet.2019.08.005",
language = "English (US)",
volume = "30",
pages = "706--719.e6",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",
}