TY - JOUR
T1 - PARPs and ADP-Ribosylation
T2 - 50 Years . . . and Counting
AU - Kraus, W. Lee
N1 - Funding Information:
The author would like to thank (1) Pierre Chambon and Masanao Miwa for agreeing to be interviewed for this piece and for providing candid answers; (2) colleagues in the field, including Ivan Ahel, Péter Bai, Paul Chang, Michael Hottiger, Anthony Leung, John Pascal, Guy Poirier, and Zhao-Qi Wang, for providing helpful suggestions about the timeline; and (3) Keun Woo Ryu and Shino Murakami for assistance with the figures. The PARP-related research in the author’s lab is supported by a grant from the NIH/NIDDK. W.L.K. declares that he is a cofounder of, and consultant for, Ribon Therapeutics, Inc.
Funding Information:
MM: In Japan, there was a funding system supported by the Ministry of Education, Science, and Culture, where leaders in Japanese scientific research could secure grants for cancer research to organize a team, including young scientists, and support their research. They met at least once a year to report their achievements. My research program was well supported by this program. There was strong competition between members of National Cancer Center Research Institute and Kyoto University. This competition was a driving force for PARP research in Japan at the time. During the meetings, I learned many things about PAR and PARPs, which were coming together as a field and obtaining a unique identity.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/6/18
Y1 - 2015/6/18
N2 - Over 50 years ago, the discovery of poly(ADP-ribose) (PAR) set a new field of science in motion-the field of poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation. The field is still flourishing today. The diversity of biological processes now known to require PARPs and ADP-ribosylation was practically unimaginable even two decades ago. From an initial focus on DNA damage detection and repair in response to genotoxic stresses, the field has expanded to include the regulation of chromatin structure, gene expression, and RNA processing in a wide range of biological systems, including reproduction, development, aging, stem cells, inflammation, metabolism, and cancer. This special focus issue of Molecular Cell includes a collection of three Reviews, three Perspectives, and a SnapShot, which together summarize the current state of the field and suggest where it may be headed.
AB - Over 50 years ago, the discovery of poly(ADP-ribose) (PAR) set a new field of science in motion-the field of poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation. The field is still flourishing today. The diversity of biological processes now known to require PARPs and ADP-ribosylation was practically unimaginable even two decades ago. From an initial focus on DNA damage detection and repair in response to genotoxic stresses, the field has expanded to include the regulation of chromatin structure, gene expression, and RNA processing in a wide range of biological systems, including reproduction, development, aging, stem cells, inflammation, metabolism, and cancer. This special focus issue of Molecular Cell includes a collection of three Reviews, three Perspectives, and a SnapShot, which together summarize the current state of the field and suggest where it may be headed.
UR - http://www.scopus.com/inward/record.url?scp=84937597366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937597366&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2015.06.006
DO - 10.1016/j.molcel.2015.06.006
M3 - Review article
C2 - 26091339
AN - SCOPUS:84937597366
SN - 1097-2765
VL - 58
SP - 902
EP - 910
JO - Molecular cell
JF - Molecular cell
IS - 6
ER -