PARP goes transcription

W. Lee Kraus; John T. Lis

doi:10.1016/S0092-8674(03)00433-1

PARP goes transcription

W. Lee Kraus, John T. Lis

Research output: Contribution to journal › Review article › peer-review

469 Scopus citations

Abstract

PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.

Original language	English (US)
Pages (from-to)	677-683
Number of pages	7
Journal	Cell
Volume	113
Issue number	6
DOIs	https://doi.org/10.1016/S0092-8674(03)00433-1
State	Published - Jun 13 2003

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(03)00433-1

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AB - PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.

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PARP goes transcription

Abstract

ASJC Scopus subject areas

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