Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma

Steven Vernino; Paul Tuite; Charles H. Adler; James F. Meschia; Bradley F. Boeve; Peter Boasberg; Joseph E. Parisi; Vanda A. Lennon

doi:10.1002/ana.10178

Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma

Steven Vernino, Paul Tuite, Charles H. Adler, James F. Meschia, Bradley F. Boeve, Peter Boasberg, Joseph E. Parisi, Vanda A. Lennon

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194 Scopus citations

Abstract

Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.

Original language	English (US)
Pages (from-to)	625-630
Number of pages	6
Journal	Annals of Neurology
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/ana.10178
State	Published - 2002

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma",

abstract = "Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.",

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T1 - Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma

AU - Vernino, Steven

AU - Tuite, Paul

AU - Adler, Charles H.

AU - Meschia, James F.

AU - Boeve, Bradley F.

AU - Boasberg, Peter

AU - Parisi, Joseph E.

AU - Lennon, Vanda A.

PY - 2002

Y1 - 2002

N2 - Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.

AB - Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.

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Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma

Abstract

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