Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma

Scott D Z Eggers; Diva R. Salomao; Robert P. Dinapoli; Steven Vernino

doi:10.4065/76.3.327

Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma

Scott D Z Eggers, Diva R. Salomao, Robert P. Dinapoli, Steven Vernino

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43 Scopus citations

Abstract

Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.

Original language	English (US)
Pages (from-to)	327-330
Number of pages	4
Journal	Mayo Clinic Proceedings
Volume	76
Issue number	3
DOIs	https://doi.org/10.4065/76.3.327
State	Published - 2001

ASJC Scopus subject areas

Medicine(all)

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10.4065/76.3.327

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title = "Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma",

abstract = "Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.",

author = "Eggers, {Scott D Z} and Salomao, {Diva R.} and Dinapoli, {Robert P.} and Steven Vernino",

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AU - Eggers, Scott D Z

AU - Salomao, Diva R.

AU - Dinapoli, Robert P.

AU - Vernino, Steven

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N2 - Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.

AB - Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.

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Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma

Abstract

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