Parametric imaging of tumor perfusion and neovascular morphology using ultrasound

Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


A new image processing strategy is detailed for the simultaneous measurement of tumor perfusion and neovascular morphology parameters from a sequence of dynamic contrast-enhanced ultrasound (DCE-US) images. A technique for locally mapping tumor perfusion parameters using skeletonized neovascular data is also introduced. Simulated images were used to test the neovascular skeletonization technique and variance (error) of relevant parametric estimates. Preliminary DCE-US image datasets were collected in 6 female patients diagnosed with invasive breast cancer and using a Philips iU22 ultrasound system equipped with a L9-3 MHz transducer and Definity contrast agent. Simulation data demonstrates that neovascular morphology parametric estimation is reproducible albeit measurement error can occur at a lower signal-to-noise ratio (SNR). Experimental results indicate the feasibility of our approach to performing both tumor perfusion and neovascular morphology measurements from DCE-US images. Future work will expand on our initial clinical findings and also extent our image processing strategy to 3-dimensional space to allow whole tumor characterization.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationUltrasonic Imaging and Tomography
ISBN (Electronic)9781628415094
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Ultrasonic Imaging and Tomography - Orlando, United States
Duration: Feb 22 2015Feb 23 2015


OtherMedical Imaging 2015: Ultrasonic Imaging and Tomography
Country/TerritoryUnited States


  • Angiogenesis
  • cancer imaging
  • contrast agent
  • neovascular morphology
  • tumor perfusion
  • ultrasound

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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