TY - JOUR
T1 - Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients
AU - De Assis, Reijâne Alves
AU - Ribeiro, Andreza Alice Feitosa
AU - Kay, Fernando Uliana
AU - Rosemberg, Laércio Alberto
AU - Nomura, Cesar Higa
AU - Loggetto, Sandra Regina
AU - Araujo, Aderson S.
AU - Fabron Junior, Antonio
AU - De Almeida Veríssimo, Mônica Pinheiro
AU - Baldanzi, Giorgio Roberto
AU - Espósito, Breno Pannia
AU - Baroni, Ronaldo Hueb
AU - Wood, John C.
AU - Hamerschlak, Nelson
N1 - Funding Information:
This study by the Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEP) received financial support from the Brazilian Ministry of Health.
PY - 2012/7
Y1 - 2012/7
N2 - Purpose: To assess the correlation between MRI findings of the pancreas with those of the heart and liver in patients with beta thalassemia; to compare the pancreas T2* MRI results with glucose and ferritin levels and labile plasma iron (LPI). Materials and methods: We retrospectively evaluated chronically transfused patients, testing glucose with enzymatic tests, serum ferritin with chemiluminescence, LPI with cellular fluorescence, and T2* MRI to assess iron content in the heart, liver, and pancreas. MRI results were compared with one another and with serum glucose, ferritin, and LPI. Liver iron concentration (LIC) was determined in 11 patients' liver biopsies by atomic absorption spectrometry. Results: 289 MRI studies were available from 115 patients during the period studied. 9.4% of patients had overt diabetes and an additional 16% of patients had impaired fasting glucose. Both pancreatic and cardiac R2* had predictive power (p < 0.0001) for identifying diabetes. Cardiac and pancreatic R2* were modestly correlated with one another (r2 = 0.20, p < 0.0001). Both were weakly correlated with LIC (r2 = 0.09, p < 0.0001 for both) and serum ferritin (r2 = 0.14, p < 0.0001 and r2 = 0.03, p < 0.02, respectively). None of the three served as a screening tool for single observations. There is a strong log-log, or power-law, relationship between ratio of signal intensity (SIR) values and pancreas R2* with an r2 of 0.91. Conclusions: Pancreatic iron overload can be assessed by MRI, but siderosis in other organs did not correlate significantly with pancreatic hemosiderosis.
AB - Purpose: To assess the correlation between MRI findings of the pancreas with those of the heart and liver in patients with beta thalassemia; to compare the pancreas T2* MRI results with glucose and ferritin levels and labile plasma iron (LPI). Materials and methods: We retrospectively evaluated chronically transfused patients, testing glucose with enzymatic tests, serum ferritin with chemiluminescence, LPI with cellular fluorescence, and T2* MRI to assess iron content in the heart, liver, and pancreas. MRI results were compared with one another and with serum glucose, ferritin, and LPI. Liver iron concentration (LIC) was determined in 11 patients' liver biopsies by atomic absorption spectrometry. Results: 289 MRI studies were available from 115 patients during the period studied. 9.4% of patients had overt diabetes and an additional 16% of patients had impaired fasting glucose. Both pancreatic and cardiac R2* had predictive power (p < 0.0001) for identifying diabetes. Cardiac and pancreatic R2* were modestly correlated with one another (r2 = 0.20, p < 0.0001). Both were weakly correlated with LIC (r2 = 0.09, p < 0.0001 for both) and serum ferritin (r2 = 0.14, p < 0.0001 and r2 = 0.03, p < 0.02, respectively). None of the three served as a screening tool for single observations. There is a strong log-log, or power-law, relationship between ratio of signal intensity (SIR) values and pancreas R2* with an r2 of 0.91. Conclusions: Pancreatic iron overload can be assessed by MRI, but siderosis in other organs did not correlate significantly with pancreatic hemosiderosis.
KW - Biopsy
KW - Blood transfusion
KW - Iron overload
KW - Magnetic resonance imaging
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U2 - 10.1016/j.ejrad.2011.03.077
DO - 10.1016/j.ejrad.2011.03.077
M3 - Article
C2 - 21501938
AN - SCOPUS:84861592761
SN - 0720-048X
VL - 81
SP - 1465
EP - 1470
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 7
ER -