TY - JOUR
T1 - Pallidal stimulation in Parkinson disease differentially modulates local and network β activity
AU - Malekmohammadi, Mahsa
AU - Shahriari, Yalda
AU - Auyong, Nicholas
AU - O'Keeffe, Andrew
AU - Bordelon, Yvette
AU - Hu, Xiao
AU - Pouratian, Nader
N1 - Funding Information:
Authors would like to thank patients who consented to participate in this study without whom recording of local field potentials would not be possible. This work was supported by the National Institutes of Biomedical Imaging and Bioengineering (K23 EB014326), National Institutes of Neurological Disorders and Stroke (R01 NS097782), philanthropic support from Casa Colina Centers for Rehabilitation, UCSF Middle-Career scientist award, and UCSF Institute of Computational Health Science. NA was supported by National Institute of Neurological Disorders and Stroke (R25 NS079198). MM was also supported by a postdoctoral fellowship from American Parkinson disease association (APDA, NY, USA).
Publisher Copyright:
© 2018 IOP Publishing Ltd.
PY - 2018/7/31
Y1 - 2018/7/31
N2 - β hypersynchrony within the basal ganglia-thalamocortical (BGTC) network has been suggested as a hallmark of Parkinson disease (PD) pathophysiology. Subthalamic nucleus (STN)-DBS has been shown to alter cortical-subcortical synchronization. It is unclear whether this is a generalizable phenomenon of therapeutic stimulation across targets. Objectives. We aimed to evaluate whether DBS of the globus pallidus internus (GPi) results in cortical-subcortical desynchronization, despite the lack of monosynaptic connections between GPi and sensorimotor cortex. Approach. We recorded local field potentials from the GPi and electrocorticographic signals from the ipsilateral sensorimotor cortex, off medications in nine PD patients, undergoing DBS implantation. We analyzed both local oscillatory power and functional connectivity (coherence and debiased weighted phase lag index (dWPLI)) with and without stimulation while subjects were resting with eyes open. Main results. DBS significantly suppressed low β power within the GPi (-26.98% ± 15.14%), p < 0.05) without modulation of sensorimotor cortical β power (low or high). In contrast, stimulation suppressed pallidocortical high β coherence (-38.89% ± 6.19%, p = 0.02) and dWPLI (-61.40% ± 8.75%, p = 0.02). Changes in cortical-subcortical functional connectivity were spatially specific to the motor cortex. Significance. We highlight the role of DBS in desynchronizing network activity, particularly in the high β band. The current study of GPi-DBS suggests these network-level effects are not necessarily dependent and potentially may be independent of the hyperdirect pathway. Importantly, these results draw a sharp distinction between the potential significance of low β oscillations locally within the basal ganglia and high β oscillations across the BGTC motor circuit.
AB - β hypersynchrony within the basal ganglia-thalamocortical (BGTC) network has been suggested as a hallmark of Parkinson disease (PD) pathophysiology. Subthalamic nucleus (STN)-DBS has been shown to alter cortical-subcortical synchronization. It is unclear whether this is a generalizable phenomenon of therapeutic stimulation across targets. Objectives. We aimed to evaluate whether DBS of the globus pallidus internus (GPi) results in cortical-subcortical desynchronization, despite the lack of monosynaptic connections between GPi and sensorimotor cortex. Approach. We recorded local field potentials from the GPi and electrocorticographic signals from the ipsilateral sensorimotor cortex, off medications in nine PD patients, undergoing DBS implantation. We analyzed both local oscillatory power and functional connectivity (coherence and debiased weighted phase lag index (dWPLI)) with and without stimulation while subjects were resting with eyes open. Main results. DBS significantly suppressed low β power within the GPi (-26.98% ± 15.14%), p < 0.05) without modulation of sensorimotor cortical β power (low or high). In contrast, stimulation suppressed pallidocortical high β coherence (-38.89% ± 6.19%, p = 0.02) and dWPLI (-61.40% ± 8.75%, p = 0.02). Changes in cortical-subcortical functional connectivity were spatially specific to the motor cortex. Significance. We highlight the role of DBS in desynchronizing network activity, particularly in the high β band. The current study of GPi-DBS suggests these network-level effects are not necessarily dependent and potentially may be independent of the hyperdirect pathway. Importantly, these results draw a sharp distinction between the potential significance of low β oscillations locally within the basal ganglia and high β oscillations across the BGTC motor circuit.
KW - Parkinson disease
KW - deep brain stimulation
KW - functional connectivity
KW - globus pallidus internus
KW - β oscillations
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U2 - 10.1088/1741-2552/aad0fb
DO - 10.1088/1741-2552/aad0fb
M3 - Article
C2 - 29972146
AN - SCOPUS:85053106816
SN - 1741-2560
VL - 15
JO - Journal of neural engineering
JF - Journal of neural engineering
IS - 5
M1 - 056016
ER -