Palladium-Catalyzed Atom-Transfer Radical Cyclization at Remote Unactivated C(sp3)−H Sites: Hydrogen-Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates

Maxim Ratushnyy; Marvin Parasram; Yang Wang; Vladimir Gevorgyan

doi:10.1002/anie.201712775

Palladium-Catalyzed Atom-Transfer Radical Cyclization at Remote Unactivated C(sp³)−H Sites: Hydrogen-Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates

Maxim Ratushnyy, Marvin Parasram, Yang Wang, Vladimir Gevorgyan

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

A novel mild, visible-light-induced palladium-catalyzed hydrogen atom translocation/atom-transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5-HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo- and heterocyclic structures.

Original language	English (US)
Pages (from-to)	2712-2715
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	10
DOIs	https://doi.org/10.1002/anie.201712775
State	Published - Mar 1 2018
Externally published	Yes

Keywords

cyclizations
hydrogen-atom transfer
palladium
photochemistry
radicals

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201712775

Cite this

Palladium-Catalyzed Atom-Transfer Radical Cyclization at Remote Unactivated C(sp³)−H Sites: Hydrogen-Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates. / Ratushnyy, Maxim; Parasram, Marvin; Wang, Yang et al.
In: Angewandte Chemie - International Edition, Vol. 57, No. 10, 01.03.2018, p. 2712-2715.

Research output: Contribution to journal › Article › peer-review

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