TY - JOUR
T1 - Oxygen Uptake Efficiency Slope and Prognosis in Heart Failure With Reduced Ejection Fraction
AU - Gordon, Jonathan
AU - Michelis, Katherine C.
AU - Pandey, Ambarish
AU - Ayers, Colby
AU - Thibodeau, Jennifer T.
AU - Grodin, Justin L.
AU - Drazner, Mark H.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/8/15
Y1 - 2023/8/15
N2 - The prognostic utility of the oxygen uptake efficiency slope (OUES) in heart failure with reduced ejection fraction is uncertain. In this post hoc analysis of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial (n = 2,074), we tested for associations of OUES and peak oxygen uptake (VO2) with heart failure hospitalization or cardiovascular death in multivariable Cox regression models, adjusting for minute ventilation/carbon dioxide production (VE/VCO2) slope and other important confounders. Harrell's C-statistics assessed the discriminatory performance of OUES and peak VO2. Lower OUES was associated with increased risk of the outcome (quartile 1 vs 4: hazard ratio 2.1 [1.5 to 2.9, p <0.001]). Peak VO2 had greater discrimination than OUES in comparable models (e.g., C-statistic = 0.73 vs 0.70, p <0.001, respectively). In the subgroup with respiratory exchange ratio <1 (n = 358), peak VO2 was associated with the outcome (p <0.001) but OUES was not (p = 0.96). In conclusion, whereas OUES was associated with clinical outcomes independently of VE/VCO2 slope, its prognostic utility was inferior to that of peak VO2, even when measured at submaximal effort.
AB - The prognostic utility of the oxygen uptake efficiency slope (OUES) in heart failure with reduced ejection fraction is uncertain. In this post hoc analysis of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial (n = 2,074), we tested for associations of OUES and peak oxygen uptake (VO2) with heart failure hospitalization or cardiovascular death in multivariable Cox regression models, adjusting for minute ventilation/carbon dioxide production (VE/VCO2) slope and other important confounders. Harrell's C-statistics assessed the discriminatory performance of OUES and peak VO2. Lower OUES was associated with increased risk of the outcome (quartile 1 vs 4: hazard ratio 2.1 [1.5 to 2.9, p <0.001]). Peak VO2 had greater discrimination than OUES in comparable models (e.g., C-statistic = 0.73 vs 0.70, p <0.001, respectively). In the subgroup with respiratory exchange ratio <1 (n = 358), peak VO2 was associated with the outcome (p <0.001) but OUES was not (p = 0.96). In conclusion, whereas OUES was associated with clinical outcomes independently of VE/VCO2 slope, its prognostic utility was inferior to that of peak VO2, even when measured at submaximal effort.
UR - http://www.scopus.com/inward/record.url?scp=85163857920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85163857920&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2023.06.033
DO - 10.1016/j.amjcard.2023.06.033
M3 - Article
C2 - 37393730
AN - SCOPUS:85163857920
SN - 0002-9149
VL - 201
SP - 273
EP - 280
JO - American Journal of Cardiology
JF - American Journal of Cardiology
ER -