Overcoming Challenges to Treat Inadequate Response in Major Depressive Disorder

George I. Papakostas, W. Clay Jackson, Roueen Rafeyan, Madhukar H. Trivedi

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


​​ ​​ When a patient with major depressive disorder experiences inadequate response to an antidepressant, clinicians should employ measurement-based care strategies to improve outcomes. Evidence suggests that adjunctive therapies, such as the FDA-approved atypical antipsychotics, are efficacious when the initial treatment is well tolerated but not improving symptoms. Clinicians should consult guidelines, peer-reviewed journals, CME programs, and other sources to stay up-to-date with current and emerging treatments in this area. They should also be familiar with the available options for psychotherapy, neurostimulation, supplements, and exercise for patients who prefer alternative therapies. ​​.

Original languageEnglish (US)
JournalThe Journal of clinical psychiatry
Issue number3
StatePublished - May 12 2020

ASJC Scopus subject areas

  • Psychiatry and Mental health


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