Over-expression of activated signal transducer and activator of transcription 3 predicts poor prognosis in upper tract urothelial carcinoma

Wei Ming Li; Chun Nung Huang; Yi Chen Lee; Szu Han Chen; Hui Hui Lin; Wen Jeng Wu; Ching Chia Li; Hsin Chih Yeh; Lin Li Chang; Wei Chi Hsu; Hung Lung Ke

doi:10.7150/ijms.17367

Over-expression of activated signal transducer and activator of transcription 3 predicts poor prognosis in upper tract urothelial carcinoma

Wei Ming Li, Chun Nung Huang, Yi Chen Lee, Szu Han Chen, Hui Hui Lin, Wen Jeng Wu, Ching Chia Li, Hsin Chih Yeh, Lin Li Chang, Wei Chi Hsu, Hung Lung Ke

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC). Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC. Results: High p-Ser-STAT3 expression was detected in 52% of UTUC patients. High p-Ser-STAT3 expression was associated with poor recurrence-free survival (p = 0.018) and overall survival (p = 0.026). In advanced cancer samples (stage T3/T4), p-Ser-STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio = 5.91, p = 0.01) and cancer-specific survival (hazard ratio = 8.83, p = 0.039). Conclusions: The expression of p-Ser-STAT3 can be a potential prognostic marker for cancer recurrence and survival in UTUC, especially in advanced stage cases.

Original language	English (US)
Pages (from-to)	1360-1367
Number of pages	8
Journal	International Journal of Medical Sciences
Volume	14
Issue number	13
DOIs	https://doi.org/10.7150/ijms.17367
State	Published - Oct 15 2017
Externally published	Yes

Keywords

Immunohistochemistry
Prognosis
Signal transducer and activator of transcription 3
Upper tract urothelial carcinoma

ASJC Scopus subject areas

General Medicine

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10.7150/ijms.17367

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Li, W. M., Huang, C. N., Lee, Y. C., Chen, S. H., Lin, H. H., Wu, W. J., Li, C. C., Yeh, H. C., Chang, L. L., Hsu, W. C., & Ke, H. L. (2017). Over-expression of activated signal transducer and activator of transcription 3 predicts poor prognosis in upper tract urothelial carcinoma. International Journal of Medical Sciences, 14(13), 1360-1367. https://doi.org/10.7150/ijms.17367

@article{dcac1a729ace4de58a10294ae0d40567,

title = "Over-expression of activated signal transducer and activator of transcription 3 predicts poor prognosis in upper tract urothelial carcinoma",

abstract = "Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC). Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC. Results: High p-Ser-STAT3 expression was detected in 52% of UTUC patients. High p-Ser-STAT3 expression was associated with poor recurrence-free survival (p = 0.018) and overall survival (p = 0.026). In advanced cancer samples (stage T3/T4), p-Ser-STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio = 5.91, p = 0.01) and cancer-specific survival (hazard ratio = 8.83, p = 0.039). Conclusions: The expression of p-Ser-STAT3 can be a potential prognostic marker for cancer recurrence and survival in UTUC, especially in advanced stage cases.",

keywords = "Immunohistochemistry, Prognosis, Signal transducer and activator of transcription 3, Upper tract urothelial carcinoma",

author = "Li, {Wei Ming} and Huang, {Chun Nung} and Lee, {Yi Chen} and Chen, {Szu Han} and Lin, {Hui Hui} and Wu, {Wen Jeng} and Li, {Ching Chia} and Yeh, {Hsin Chih} and Chang, {Lin Li} and Hsu, {Wei Chi} and Ke, {Hung Lung}",

note = "Funding Information: This study was supported by grants from Kaohsiung Medical University “Aim for the Top Universities” (KMU-TP104E31, KMU-TP105G00, KMU-TP105G01 and KMU-TP105G025), The Health and Welfare Surcharge of Tobacco Products, Ministry of Health and Welfare (MOHW106-TDU-B-212 -144007), Ministry of Science and Technology (MOST106-2314-B-037-092), and Kaohsiung Medical University Hospital (KMUH102-2R42 and KMUH103-3T11). Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2017",

month = oct,

day = "15",

doi = "10.7150/ijms.17367",

language = "English (US)",

volume = "14",

pages = "1360--1367",

journal = "International Journal of Medical Sciences",

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TY - JOUR

T1 - Over-expression of activated signal transducer and activator of transcription 3 predicts poor prognosis in upper tract urothelial carcinoma

AU - Li, Wei Ming

AU - Huang, Chun Nung

AU - Lee, Yi Chen

AU - Chen, Szu Han

AU - Lin, Hui Hui

AU - Wu, Wen Jeng

AU - Li, Ching Chia

AU - Yeh, Hsin Chih

AU - Chang, Lin Li

AU - Hsu, Wei Chi

AU - Ke, Hung Lung

N1 - Funding Information: This study was supported by grants from Kaohsiung Medical University “Aim for the Top Universities” (KMU-TP104E31, KMU-TP105G00, KMU-TP105G01 and KMU-TP105G025), The Health and Welfare Surcharge of Tobacco Products, Ministry of Health and Welfare (MOHW106-TDU-B-212 -144007), Ministry of Science and Technology (MOST106-2314-B-037-092), and Kaohsiung Medical University Hospital (KMUH102-2R42 and KMUH103-3T11). Publisher Copyright: © Ivyspring International Publisher.

PY - 2017/10/15

Y1 - 2017/10/15

N2 - Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC). Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC. Results: High p-Ser-STAT3 expression was detected in 52% of UTUC patients. High p-Ser-STAT3 expression was associated with poor recurrence-free survival (p = 0.018) and overall survival (p = 0.026). In advanced cancer samples (stage T3/T4), p-Ser-STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio = 5.91, p = 0.01) and cancer-specific survival (hazard ratio = 8.83, p = 0.039). Conclusions: The expression of p-Ser-STAT3 can be a potential prognostic marker for cancer recurrence and survival in UTUC, especially in advanced stage cases.

AB - Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC). Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC. Results: High p-Ser-STAT3 expression was detected in 52% of UTUC patients. High p-Ser-STAT3 expression was associated with poor recurrence-free survival (p = 0.018) and overall survival (p = 0.026). In advanced cancer samples (stage T3/T4), p-Ser-STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio = 5.91, p = 0.01) and cancer-specific survival (hazard ratio = 8.83, p = 0.039). Conclusions: The expression of p-Ser-STAT3 can be a potential prognostic marker for cancer recurrence and survival in UTUC, especially in advanced stage cases.

KW - Immunohistochemistry

KW - Prognosis

KW - Signal transducer and activator of transcription 3

KW - Upper tract urothelial carcinoma

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DO - 10.7150/ijms.17367

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AN - SCOPUS:85034267304

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JO - International Journal of Medical Sciences

JF - International Journal of Medical Sciences

IS - 13

ER -

Over-expression of activated signal transducer and activator of transcription 3 predicts poor prognosis in upper tract urothelial carcinoma

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