Ovarian serous carcinogenesis from tubal secretory cells

Wenjing Zhang, Linxuan Wei, Lingmin Li, Binlie Yang, Beihua Kong, Guang Yao, Wenxin Zheng

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Due to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both high- and lowgrade ovarian serous cancers were recently found to originate not in the ovaries, but rather from the secretory cells of the fallopian tube, mostly from the tubal fimbriated ends. In this article, we review the evidentiary basis for the aforementioned paradigm shift in the cell origin of ovarian serous cancers, as well as its potential clinical implications.

Original languageEnglish (US)
Pages (from-to)1295-1302
Number of pages8
JournalHistology and Histopathology
Issue number11
StatePublished - Nov 2015


  • Fallopian tube
  • HGSC
  • LGSC
  • Ovarian serous carcinoma
  • Secretory cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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