TY - JOUR
T1 - Outcomes of Squamous Cell Carcinoma of the Lip Treated with Mohs Micrographic Surgery
T2 - A Retrospective Cohort Study
AU - Nadir, Umer
AU - Le, Kim
AU - Shi, Kevin
AU - Srivastava, Divya
AU - Nijhawan, Rajiv I.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - BACKGROUNDCutaneous squamous cell carcinomas (cSCCs) of the lip have been reported to be at higher risk for poorer post-treatment outcomes.OBJECTIVETo examine outcomes of patients with SCC of the lip treated with Mohs micrographic surgery (MMS) and identify factors for recurrence.MATERIALS AND METHODSThis retrospective review of a single tertiary referral center's Mohs case logs from 2010 to 2019 identified cases of lip SCC. Clinicopathologic characteristics and outcomes (local recurrence [LR], metastasis, and disease-specific death) were reviewed.RESULTSOne hundred ninety cases of SCC of the lip were identified and demonstrated that MMS offered a disease-free survival of 96.8% over an average follow-up period of 42 months. Younger age (61 vs 74 years p =.006), increased MMS stages (p =.009), and higher American Joint Committee on Cancer and Brigham and Women's Hospital T stages were risk factors for LR. Immunosuppression, large tumor size, mucosal lip involvement, aggressive histology, and perineural invasion were not associated with LR.CONCLUSIONThe results of this study show that SCC of the lip behaved similarly to cSCC outside the lip area, and that both primary and recurrent lesions can be treated effectively with MMS.
AB - BACKGROUNDCutaneous squamous cell carcinomas (cSCCs) of the lip have been reported to be at higher risk for poorer post-treatment outcomes.OBJECTIVETo examine outcomes of patients with SCC of the lip treated with Mohs micrographic surgery (MMS) and identify factors for recurrence.MATERIALS AND METHODSThis retrospective review of a single tertiary referral center's Mohs case logs from 2010 to 2019 identified cases of lip SCC. Clinicopathologic characteristics and outcomes (local recurrence [LR], metastasis, and disease-specific death) were reviewed.RESULTSOne hundred ninety cases of SCC of the lip were identified and demonstrated that MMS offered a disease-free survival of 96.8% over an average follow-up period of 42 months. Younger age (61 vs 74 years p =.006), increased MMS stages (p =.009), and higher American Joint Committee on Cancer and Brigham and Women's Hospital T stages were risk factors for LR. Immunosuppression, large tumor size, mucosal lip involvement, aggressive histology, and perineural invasion were not associated with LR.CONCLUSIONThe results of this study show that SCC of the lip behaved similarly to cSCC outside the lip area, and that both primary and recurrent lesions can be treated effectively with MMS.
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U2 - 10.1097/DSS.0000000000003992
DO - 10.1097/DSS.0000000000003992
M3 - Article
C2 - 37910651
AN - SCOPUS:85178498106
SN - 1076-0512
VL - 49
SP - 1108
EP - 1111
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 12
ER -