TY - JOUR
T1 - Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention After a Previous Failed Attempt
AU - Rempakos, Athanasios
AU - Kostantinis, Spyridon
AU - Simsek, Bahadir
AU - Karacsonyi, Judit
AU - Choi, James W.
AU - Poommipanit, Paul
AU - Khatri, Jaikirshan J.
AU - Jaber, Wissam
AU - Rinfret, Stephane
AU - Nicholson, William
AU - Gorgulu, Sevket
AU - Jaffer, Farouc A.
AU - Chandwaney, Raj
AU - Ybarra, Luiz F.
AU - Bagur, Rodrigo
AU - Alaswad, Khaldoon
AU - Krestyaninov, Oleg
AU - Khelimskii, Dmitrii
AU - Karmpaliotis, Dimitrios
AU - Uretsky, Barry F.
AU - Soylu, Korhan
AU - Yildirim, Ufuk
AU - Potluri, Srinivasa
AU - Rangan, Bavana V.
AU - Mastrodemos, Olga C.
AU - Allana, Salman
AU - Sandoval, Yader
AU - Burke, Nicholas M.
AU - Brilakis, Emmanouil S.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/4/15
Y1 - 2023/4/15
N2 - The impact of a previous failure on procedural techniques and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. We examined the clinical and angiographic characteristics and procedural outcomes of 9,393 patients who underwent 9,560 CTO PCIs at 42 United States and non-United States centers between 2012 and 2022. A total of 1,904 CTO lesions (20%) had a previous failed PCI attempt. Patients who underwent reattempt CTO PCI were more likely to have a family history of coronary artery disease (37% vs 31%, p <0.001) and dyslipidemia (87.9% vs 84.3%, p <0.001) but were less likely to have heart failure (25.1% vs 29.5%; p <0.001) and cerebrovascular disease (8.7% vs 10.4%, p = 0.04). Patients with previous failure had a higher Japanese CTO (3.33 ± 1.16 vs 2.12 ± 1.19, p <0.001) score and required longer procedure (120 vs 111 minutes, p <0.001) and fluoroscopy (46.9 vs 40.4 minutes, p <0.001) times and higher air kerma radiation dose (2.3 vs 2.1 gray, p = 0.013). Technical success rates (84.3% vs 86.5%, p = 0.011) were lower in patients with a previous failure compared with patients who underwent first-attempt CTO PCI with no significant difference in in-hospital major adverse cardiac events. After adjusting for potential confounders, a previous failure was not associated with technical failure. Operators performing >30 CTO PCIs annually were more likely to achieve technical success in patients with previous failure. In conclusion, a previous failed CTO PCI attempt was associated with higher lesion complexity, longer procedure time, and lower technical success; however, the association with lower technical success did not remain significant in multivariable analysis.
AB - The impact of a previous failure on procedural techniques and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. We examined the clinical and angiographic characteristics and procedural outcomes of 9,393 patients who underwent 9,560 CTO PCIs at 42 United States and non-United States centers between 2012 and 2022. A total of 1,904 CTO lesions (20%) had a previous failed PCI attempt. Patients who underwent reattempt CTO PCI were more likely to have a family history of coronary artery disease (37% vs 31%, p <0.001) and dyslipidemia (87.9% vs 84.3%, p <0.001) but were less likely to have heart failure (25.1% vs 29.5%; p <0.001) and cerebrovascular disease (8.7% vs 10.4%, p = 0.04). Patients with previous failure had a higher Japanese CTO (3.33 ± 1.16 vs 2.12 ± 1.19, p <0.001) score and required longer procedure (120 vs 111 minutes, p <0.001) and fluoroscopy (46.9 vs 40.4 minutes, p <0.001) times and higher air kerma radiation dose (2.3 vs 2.1 gray, p = 0.013). Technical success rates (84.3% vs 86.5%, p = 0.011) were lower in patients with a previous failure compared with patients who underwent first-attempt CTO PCI with no significant difference in in-hospital major adverse cardiac events. After adjusting for potential confounders, a previous failure was not associated with technical failure. Operators performing >30 CTO PCIs annually were more likely to achieve technical success in patients with previous failure. In conclusion, a previous failed CTO PCI attempt was associated with higher lesion complexity, longer procedure time, and lower technical success; however, the association with lower technical success did not remain significant in multivariable analysis.
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U2 - 10.1016/j.amjcard.2023.01.045
DO - 10.1016/j.amjcard.2023.01.045
M3 - Article
C2 - 36871531
AN - SCOPUS:85149409597
SN - 0002-9149
VL - 193
SP - 61
EP - 69
JO - American Journal of Cardiology
JF - American Journal of Cardiology
ER -