Otitis media in infants aged 0-8 weeks: Frequency of associated serious bacterial disease

Charles A. Nozicka, June G. Hanly, David J. Beste, Stephen F. Conley, Halim M. Hennes

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective: To determine the frequency of serious bacterial infection in well appearing infants aged 0-8 weeks with isolated otitis media (OM). Methods: Infants with confirmed OM underwent tympanocentesis with middle ear fluid (MEF) culture and complete sepsis evaluation. Enrolled infants were admitted to the hospital for parenteral antibiotics until blood, urine, and CSF cultures were negative for 48 hours. Results: Forty non-toxic appearing infants were enrolled between January 1994 and April 1995, of whom 15 (38%) had a documented rectal temperature ≥38°C. Bacterial pathogens were isolated from MEF cultures in 25 (62.5%) infants. All afebrile infants had negative blood, urine, and cerebrospinal fluid cultures (upper limit (UL) 95 % CI 0.11). Only two febrile infants had positive cultures from sites other than the MEF (UL 95% CI 0.36). Conclusion: In our study population, previously healthy, non-toxic appearing afebrile infants aged 2-8 weeks and having isolated OM infrequently have an associated serious bacterial infection, suggesting that outpatient treatment with oral antibiotics and close follow-up may be an option. Further studies with large numbers of infants are necessary to confirm this conclusion.

Original languageEnglish (US)
Pages (from-to)252-254
Number of pages3
JournalPediatric emergency care
Issue number4
StatePublished - Aug 1999


  • Infants
  • Otitis media
  • Sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine


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