Osteoinduction using bone morphogenic protein in irradiated tissue

Brian K. Howard, Karla R. Brown, Joseph L. Leach, Cheng Hui Chang, David I. Rosenthal

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objective: To prove the efficacy of bone morphogenic protein as an osteoinductive agent in irradiated tissue. Design: Prospective randomized controlled trial designed to test the effectiveness of recombinant bone morphogenic protein 2 (rBMP-2) combined with solid hydroxyapatite disks in an irradiated tissue bed. Subjects: Eighteen adult, male, white New Zealand rabbits weighing 3.0 to 3.5 kg. Intervention: The rabbits were randomly divided, with 9 receiving radiation treatment and 9 receiving no radiation treatment. Each animal underwent implantation of 2 hydroxyapatite disks onto the snout at 9 weeks following radiation treatment. One disk was impregnated with rBMP-2 and the other with buffer only. The animals were killed at 3, 6, or 20 weeks after implantation for analysis. Results: Histological analysis demonstrated that rBMP-2 was equally effective as an osteoinductive agent in the irradiated and nonirradiated tissue. We also found significantly increased new bone formation in the rBMP-2 group vs the buffer group. Conclusions: This study supports the potential clinical utility of rBMP-2 and solid hydroxyapatite in irradiated tissue beds. These findings have interesting implications for patients with head and neck cancer who have undergone radiation therapy and need bony reconstruction.

Original languageEnglish (US)
Pages (from-to)985-988
Number of pages4
JournalArchives of Otolaryngology - Head and Neck Surgery
Issue number9
StatePublished - Sep 1998

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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