Orexin Neurons and the TASK of Glucosensing

Michael M. Scott; Jacob N. Marcus; Joel K. Elmquist

doi:10.1016/j.neuron.2006.05.014

Orexin Neurons and the TASK of Glucosensing

Michael M. Scott, Jacob N. Marcus, Joel K. Elmquist

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Relatively little is known about the mechanisms that link changing levels of glucose and neuronal activity. A paper in the current issue of Neuron by Burdakov et al. demonstrates that orexin/hypocretin neurons are inhibited by rising glucose in part due to membrane potential effects mediated by tandem-pore K⁺ (K_2P) channels. The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	Neuron
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2006.05.014
State	Published - Jun 1 2006

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neuron.2006.05.014

Cite this

@article{359258788b6f46eda96a4662f0d25a6e,

title = "Orexin Neurons and the TASK of Glucosensing",

abstract = "Relatively little is known about the mechanisms that link changing levels of glucose and neuronal activity. A paper in the current issue of Neuron by Burdakov et al. demonstrates that orexin/hypocretin neurons are inhibited by rising glucose in part due to membrane potential effects mediated by tandem-pore K+ (K2P) channels. The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses.",

author = "Scott, {Michael M.} and Marcus, {Jacob N.} and Elmquist, {Joel K.}",

year = "2006",

month = jun,

day = "1",

doi = "10.1016/j.neuron.2006.05.014",

language = "English (US)",

volume = "50",

pages = "665--667",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Orexin Neurons and the TASK of Glucosensing

AU - Scott, Michael M.

AU - Marcus, Jacob N.

AU - Elmquist, Joel K.

PY - 2006/6/1

Y1 - 2006/6/1

N2 - Relatively little is known about the mechanisms that link changing levels of glucose and neuronal activity. A paper in the current issue of Neuron by Burdakov et al. demonstrates that orexin/hypocretin neurons are inhibited by rising glucose in part due to membrane potential effects mediated by tandem-pore K+ (K2P) channels. The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses.

AB - Relatively little is known about the mechanisms that link changing levels of glucose and neuronal activity. A paper in the current issue of Neuron by Burdakov et al. demonstrates that orexin/hypocretin neurons are inhibited by rising glucose in part due to membrane potential effects mediated by tandem-pore K+ (K2P) channels. The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses.

UR - http://www.scopus.com/inward/record.url?scp=33646932667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646932667&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2006.05.014

DO - 10.1016/j.neuron.2006.05.014

M3 - Short survey

C2 - 16731504

AN - SCOPUS:33646932667

SN - 0896-6273

VL - 50

SP - 665

EP - 667

JO - Neuron

JF - Neuron

IS - 5

ER -

Orexin Neurons and the TASK of Glucosensing

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this