Orexin Neurons and the TASK of Glucosensing

Michael M. Scott, Jacob N. Marcus, Joel K. Elmquist

Research output: Contribution to journalShort surveypeer-review

6 Scopus citations


Relatively little is known about the mechanisms that link changing levels of glucose and neuronal activity. A paper in the current issue of Neuron by Burdakov et al. demonstrates that orexin/hypocretin neurons are inhibited by rising glucose in part due to membrane potential effects mediated by tandem-pore K+ (K2P) channels. The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
Issue number5
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)


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