Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Toshiaki Nakamura; Kazuhide Uramura; Tadahiro Nambu; Toshihiko Yada; Katsutoshi Goto; Masashi Yanagisawa; Takeshi Sakurai

doi:10.1016/S0006-8993(00)02555-5

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Toshiaki Nakamura, Kazuhide Uramura, Tadahiro Nambu, Toshihiko Yada, Katsutoshi Goto, Masashi Yanagisawa, Takeshi Sakurai

Research output: Contribution to journal › Article › peer-review

319 Scopus citations

Abstract

We demonstrated involvement of the ventral tegmental area (VTA) dopaminergic system in orexin-induced hyperlocomotion and stereotypy in rats. In double-label immunohistochemical study of rat brain, we found that tyrosine hydroxylase (TH)-immunoreactive cells in the VTA received innervation from orexin immunoreactive-fibers. Orexin-A induced an increase in [Ca²⁺](i) in isolated A10 dopamine neurons in a dose-dependent manner. In behavioral studies, we found that orexin-A induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine D₂ (haloperidol and sulpiride) or D₁ (SCH23390) antagonists. These results suggest that the orexin-induced hyperlocomotion, stereotypy and grooming behavior are mediated by the dopaminergic system and this pathway might be involved in orexin-induced emotional responses. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	181-187
Number of pages	7
Journal	Brain Research
Volume	873
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(00)02555-5
State	Published - Aug 4 2000

Keywords

Hyperlocomotion
Orexin
Stereotypy, Dopamine
Ventral tegmental area

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system",

abstract = "We demonstrated involvement of the ventral tegmental area (VTA) dopaminergic system in orexin-induced hyperlocomotion and stereotypy in rats. In double-label immunohistochemical study of rat brain, we found that tyrosine hydroxylase (TH)-immunoreactive cells in the VTA received innervation from orexin immunoreactive-fibers. Orexin-A induced an increase in [Ca2+](i) in isolated A10 dopamine neurons in a dose-dependent manner. In behavioral studies, we found that orexin-A induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine D2 (haloperidol and sulpiride) or D1 (SCH23390) antagonists. These results suggest that the orexin-induced hyperlocomotion, stereotypy and grooming behavior are mediated by the dopaminergic system and this pathway might be involved in orexin-induced emotional responses. Copyright (C) 2000 Elsevier Science B.V.",

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author = "Toshiaki Nakamura and Kazuhide Uramura and Tadahiro Nambu and Toshihiko Yada and Katsutoshi Goto and Masashi Yanagisawa and Takeshi Sakurai",

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AU - Nakamura, Toshiaki

AU - Uramura, Kazuhide

AU - Nambu, Tadahiro

AU - Yada, Toshihiko

AU - Goto, Katsutoshi

AU - Yanagisawa, Masashi

AU - Sakurai, Takeshi

PY - 2000/8/4

Y1 - 2000/8/4

N2 - We demonstrated involvement of the ventral tegmental area (VTA) dopaminergic system in orexin-induced hyperlocomotion and stereotypy in rats. In double-label immunohistochemical study of rat brain, we found that tyrosine hydroxylase (TH)-immunoreactive cells in the VTA received innervation from orexin immunoreactive-fibers. Orexin-A induced an increase in [Ca2+](i) in isolated A10 dopamine neurons in a dose-dependent manner. In behavioral studies, we found that orexin-A induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine D2 (haloperidol and sulpiride) or D1 (SCH23390) antagonists. These results suggest that the orexin-induced hyperlocomotion, stereotypy and grooming behavior are mediated by the dopaminergic system and this pathway might be involved in orexin-induced emotional responses. Copyright (C) 2000 Elsevier Science B.V.

AB - We demonstrated involvement of the ventral tegmental area (VTA) dopaminergic system in orexin-induced hyperlocomotion and stereotypy in rats. In double-label immunohistochemical study of rat brain, we found that tyrosine hydroxylase (TH)-immunoreactive cells in the VTA received innervation from orexin immunoreactive-fibers. Orexin-A induced an increase in [Ca2+](i) in isolated A10 dopamine neurons in a dose-dependent manner. In behavioral studies, we found that orexin-A induced hyperlocomotion, stereotypy and grooming behavior when administered centrally in rats, and these effects were abolished by dopamine D2 (haloperidol and sulpiride) or D1 (SCH23390) antagonists. These results suggest that the orexin-induced hyperlocomotion, stereotypy and grooming behavior are mediated by the dopaminergic system and this pathway might be involved in orexin-induced emotional responses. Copyright (C) 2000 Elsevier Science B.V.

KW - Hyperlocomotion

KW - Orexin

KW - Stereotypy, Dopamine

KW - Ventral tegmental area

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Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

Abstract

Keywords

ASJC Scopus subject areas

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