@article{1a1dcd627e56454e8ec0e850b3c7627e,
title = "Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration",
abstract = "15-Prostaglandin dehydrogenase (15-PGDH) regulates the concentration of prostaglandin E2 in vivo. Inhibitors of 15-PGDH elevate PGE2 levels and promote tissue repair and regeneration. Here, we describe a novel class of quinoxaline amides that show potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.",
author = "Bin Hu and Kosuke Toda and Xiaoyu Wang and Antczak, {Monika I.} and Julianne Smith and Sophie Geboers and Gen Nishikawa and Hongyun Li and Dawn Dawson and Stephen Fink and Desai, {Amar B.} and Williams, {Noelle S.} and Markowitz, {Sanford D.} and Ready, {Joseph M.}",
note = "Funding Information: Funding was provided by the Welch Foundation (I-1612, J.M.R.), NIH (R01CA216863 RM1GM142002 to J.M.R, S.D.M; R35CA197442 to S.D.M.; R50CA211119 to S.F.). Publisher Copyright: {\textcopyright} 2022 Authors. All rights reserved.",
year = "2022",
month = nov,
day = "24",
doi = "10.1021/acs.jmedchem.2c01299",
language = "English (US)",
volume = "65",
pages = "15327--15343",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "22",
}