Oral combination therapy: Repaglinide plus metformin for treatment of type 2 diabetes

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Type 2 diabetes is characterized by decreases in insulin secretion and insulin sensitivity. Several classes of oral antidiabetic medications are currently approved for the treatment of type 2 diabetes. A stepwise treatment approach from monotherapy to combination therapy is traditionally used; however, the frequency of treatment failure with monotherapy has resulted in a move towards earlier treatment with combination therapies that target the two principal defects in glycaemic control. One such combination regimen is repaglinide (a prandial glucose regulator that increases insulin release) plus metformin (an insulin sensitizer that inhibits hepatic glucose output, increases peripheral glucose uptake and utilization and minimizes weight gain). Findings from several clinical trials have shown that combination therapy with repaglinide plus metformin is well tolerated and results in greater reductions of haemoglobin A1c and fasting plasma glucose values compared with either monotherapy. Repaglinide may also provide a more suitable alternative to combination therapy with sulphonylureas and metformin because of its reduced propensity for hypoglycaemia. The combination regimen of repaglinide plus metformin should therefore be considered as a valuable option in the management of patients with type 2 diabetes when monotherapy is no longer adequate.

Original languageEnglish (US)
Pages (from-to)1167-1177
Number of pages11
JournalDiabetes, Obesity and Metabolism
Issue number12
StatePublished - Jan 1 2008


  • Fixed-combination treatment
  • Metformin
  • Repaglinide
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Oral combination therapy: Repaglinide plus metformin for treatment of type 2 diabetes'. Together they form a unique fingerprint.

Cite this