Optogenetic approach to the studies of synaptic transmission

D. N. Artamonov; V. V. Korzhova; O. L. Vlasova; I. B. Bezprozvannyi

doi:10.1007/s10517-014-2577-y

Optogenetic approach to the studies of synaptic transmission

D. N. Artamonov, V. V. Korzhova, O. L. Vlasova, I. B. Bezprozvannyi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Optogenetics is a modern nanobiological approaches allowing modulation of the physiological status of electrostimulated cells, including the neurons. The optogenetic approach was used to evaluate the efficiency of synaptic transmission between the neurons in a mixed corticostriatal culture. Synaptic contacts between the cortical and striatal neurons forming in a mixed culture could be modulated by the opticogenetic methods. Studies of the synaptic interactions between the neurons were essential for understanding the disease mechanisms, and therefore, this method seemed to be promising for biomedical studies.

Original language	English (US)
Pages (from-to)	404-407
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	157
Issue number	3
DOIs	https://doi.org/10.1007/s10517-014-2577-y
State	Published - Jul 2014

Keywords

neuron culture
opsins
optogenetics
synaptic transmission

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/s10517-014-2577-y

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abstract = "Optogenetics is a modern nanobiological approaches allowing modulation of the physiological status of electrostimulated cells, including the neurons. The optogenetic approach was used to evaluate the efficiency of synaptic transmission between the neurons in a mixed corticostriatal culture. Synaptic contacts between the cortical and striatal neurons forming in a mixed culture could be modulated by the opticogenetic methods. Studies of the synaptic interactions between the neurons were essential for understanding the disease mechanisms, and therefore, this method seemed to be promising for biomedical studies.",

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AU - Bezprozvannyi, I. B.

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N2 - Optogenetics is a modern nanobiological approaches allowing modulation of the physiological status of electrostimulated cells, including the neurons. The optogenetic approach was used to evaluate the efficiency of synaptic transmission between the neurons in a mixed corticostriatal culture. Synaptic contacts between the cortical and striatal neurons forming in a mixed culture could be modulated by the opticogenetic methods. Studies of the synaptic interactions between the neurons were essential for understanding the disease mechanisms, and therefore, this method seemed to be promising for biomedical studies.

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Optogenetic approach to the studies of synaptic transmission

Abstract

Keywords

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