TY - JOUR
T1 - Optical molecular imaging for tumor detection and image-guided surgery
AU - Wang, Chensu
AU - Wang, Zhaohui
AU - Zhao, Tian
AU - Li, Yang
AU - Huang, Gang
AU - Sumer, Baran D.
AU - Gao, Jinming
N1 - Funding Information:
This work was supported by the grant from the National Institutes of Health ( R01CA192221 and R01CA211930 to J.G. and B.D.S.). C.W. was a Howard Hughes Medical Institute (HHMI) International Student Research Fellow. Fig. 1 is based on data generated by the TCGA Research Network: http://cancergenome.nih.gov/ .
Publisher Copyright:
© 2017
PY - 2018/3
Y1 - 2018/3
N2 - We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to cancer cells or tumor microenvironment, such as cell surface receptors, hypoxia, secreted proteases and extracellular acidosis have been characterized, and can be used to distinguish cancer from normal tissue. A variety of optical imaging probes have been developed to target these biomarkers to improve tumor contrast over the background tissue. Unlike conventional anatomical and molecular imaging technologies, fluorescent imaging method benefits from its safety, high-spatial resolution and real-time capability, and therefore, has become a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. In this review, we summarize recent progress in ‘always-ON’ and stimuli-activatable fluorescent imaging probes, and discuss their potentials in tumor detection and image-guided surgery.
AB - We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to cancer cells or tumor microenvironment, such as cell surface receptors, hypoxia, secreted proteases and extracellular acidosis have been characterized, and can be used to distinguish cancer from normal tissue. A variety of optical imaging probes have been developed to target these biomarkers to improve tumor contrast over the background tissue. Unlike conventional anatomical and molecular imaging technologies, fluorescent imaging method benefits from its safety, high-spatial resolution and real-time capability, and therefore, has become a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. In this review, we summarize recent progress in ‘always-ON’ and stimuli-activatable fluorescent imaging probes, and discuss their potentials in tumor detection and image-guided surgery.
KW - Cancer diagnosis
KW - Cancer molecular imaging
KW - Image-guided surgery
KW - Stimuli-responsive nanomaterials
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85037808831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037808831&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2017.12.002
DO - 10.1016/j.biomaterials.2017.12.002
M3 - Review article
C2 - 29245052
AN - SCOPUS:85037808831
SN - 0142-9612
VL - 157
SP - 62
EP - 75
JO - Biomaterials
JF - Biomaterials
ER -