Opioid addiction. Recent advances in detoxification and maintenance therapy

Susan E. Best; Alison H. Oliveto; Thomas R. Kosten

doi:10.2165/00023210-199606040-00005

Opioid addiction. Recent advances in detoxification and maintenance therapy

Susan E. Best, Alison H. Oliveto, Thomas R. Kosten

Psychiatry

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

New pharmacological treatments for opioid dependence include detoxification agents such as clonidine and lofexidine, and maintenance agents such as levacetylmethadol (levo-α-acetylmethadol; LAAM) and buprenorphine. Detoxification from opioids has been facilitated by the development of clonidine, particularly in combination with naltrexone. New experimental approaches have also been tried to reduce the time that it takes to complete the process of detoxification or to further reduce residual withdrawal symptoms not completely relieved by clonidine. Maintenance on levacetylmethadol or buprenorphine has become a viable alternative to methadone maintenance and holds promise for the future.

Original language	English (US)
Pages (from-to)	301-314
Number of pages	14
Journal	CNS Drugs
Volume	6
Issue number	4
DOIs	https://doi.org/10.2165/00023210-199606040-00005
State	Published - Jan 1 1996

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

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AB - New pharmacological treatments for opioid dependence include detoxification agents such as clonidine and lofexidine, and maintenance agents such as levacetylmethadol (levo-α-acetylmethadol; LAAM) and buprenorphine. Detoxification from opioids has been facilitated by the development of clonidine, particularly in combination with naltrexone. New experimental approaches have also been tried to reduce the time that it takes to complete the process of detoxification or to further reduce residual withdrawal symptoms not completely relieved by clonidine. Maintenance on levacetylmethadol or buprenorphine has become a viable alternative to methadone maintenance and holds promise for the future.

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Opioid addiction. Recent advances in detoxification and maintenance therapy

Abstract

ASJC Scopus subject areas

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