Open hepatic resection in the elderly at two tertiary referral centers

Jessica L. Mueller, George Molina, Cristina R. Ferrone, David C. Chang, Parsia Vagefi, Kenneth K. Tanabe, Thomas E. Clancy, Motaz Qadan

Research output: Contribution to journalArticlepeer-review


Background: Surgeons are being increasingly called upon to operate on the very elderly. This study aimed to evaluate outcomes following hepatectomy in patients ≥80 years of age at two tertiary care centers. Methods: All adult patients who underwent liver resection from 2001 to 2017 were included. Primary outcome was 90-day postoperative mortality. Secondary outcomes included 30-day postoperative mortality and postoperative complications. Results: Between 2001 and 2017, 2397 patients underwent liver resection. On unadjusted analysis, patients ≥80 years of age had higher rates of 90-day mortality (13.3% vs. 3.6%, p < 0.001), 30-day mortality (5.6% vs. 1.8%, p = 0.01), MI (7.9% vs. 3.5%, p = 0.04), and UTI (10.0% vs. 4.5%, p = 0.02). On multivariable analysis, age ≥80 years was significantly associated with 90-day postoperative mortality (OR 4.51, 95%CI 2.11–9.67, p < 0.001). Conclusions: Across these two major referral tertiary care centers, very elderly patients had higher rates of 90-day and 30-day postoperative mortality on both unadjusted and adjusted analyses.

Original languageEnglish (US)
Pages (from-to)594-598
Number of pages5
JournalAmerican journal of surgery
Issue number3
StatePublished - Sep 2021
Externally publishedYes


  • Elderly
  • Hepatectomy
  • Liver resection
  • Morbidity
  • Mortality
  • Octogenarian

ASJC Scopus subject areas

  • Surgery


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