Oncocytic mania: A review of oncocytic lesions throughout the body

F. Guaraldi, G. Zang, A. P. Dackiw, P. Caturegli

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Oncocytic lesions are characterized pathologically by an abundance of oncocytes, that is by enlarged, eosinophilic, and finely granular cells enriched in mitochondria. They can arise in numerous organs and tissues, often in endocrine glands, and have been associated with hyperplasia, autoimmunity, and neoplasia. The causes and mechanisms that transform a normal cell into an oncocyte remain to be elucidated. Aim of this article is to review the most common oncocytic lesions, highlighting their key pathological features and clinical significance.

Original languageEnglish (US)
Pages (from-to)383-394
Number of pages12
JournalJournal of Endocrinological Investigation
Issue number5
StatePublished - May 2011


  • Oncocyte
  • Oncocytic tumor
  • Oncocytoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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