TY - JOUR
T1 - OnabotulinumtoxinA improves oral aperture in patients with scleroderma
T2 - A small clinical trial
AU - Gonzalez, Cristian D.
AU - Pamatmat, Jarod John
AU - Burningham, Kevin M.
AU - Yang, Michelle
AU - Goff, Heather W.
N1 - Publisher Copyright:
© 2023 American Academy of Dermatology, Inc.
PY - 2023/11
Y1 - 2023/11
N2 - Background: Reduced oral aperture (ROA), resulting from systemic sclerosis (SSc), is a debilitating condition with limited treatment options. Improvement in oral function has been reported with perioral administration of botulinum toxin type A. Objective: To prospectively evaluate the efficacy of onabotulinumtoxinA (onabotA) injection in improving oral opening and quality of life in SSc patients with ROA. Methods: Seventeen women with SSc and ROA were treated with 16 units of onabotA in 8 different sites around the cutaneous lips. Measurements of maximum mouth opening were taken before treatment, at 2 weeks posttreatment, and at 3 months posttreatment. Function and quality of life were also assessed via surveys. Results: Interincisor and interlabial distances were significantly increased 2 weeks after treatment with onabotA (P < .001) but not 3 months after. Subjective improvement in quality of life was noted. Limitations: This single-institution study enrolled 17 patients and did not have a placebo control group. Conclusion: OnabotA appears to have a strong short-term symptomatic benefit in patients with ROA due to SSc, with possible benefit to quality of life.
AB - Background: Reduced oral aperture (ROA), resulting from systemic sclerosis (SSc), is a debilitating condition with limited treatment options. Improvement in oral function has been reported with perioral administration of botulinum toxin type A. Objective: To prospectively evaluate the efficacy of onabotulinumtoxinA (onabotA) injection in improving oral opening and quality of life in SSc patients with ROA. Methods: Seventeen women with SSc and ROA were treated with 16 units of onabotA in 8 different sites around the cutaneous lips. Measurements of maximum mouth opening were taken before treatment, at 2 weeks posttreatment, and at 3 months posttreatment. Function and quality of life were also assessed via surveys. Results: Interincisor and interlabial distances were significantly increased 2 weeks after treatment with onabotA (P < .001) but not 3 months after. Subjective improvement in quality of life was noted. Limitations: This single-institution study enrolled 17 patients and did not have a placebo control group. Conclusion: OnabotA appears to have a strong short-term symptomatic benefit in patients with ROA due to SSc, with possible benefit to quality of life.
KW - diffuse scleroderma
KW - limited mouth opening
KW - microstomia
KW - neuromodulator
KW - onabotulinumtoxinA
KW - reduced oral aperture
KW - scleroderma
KW - systemic sclerosis
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U2 - 10.1016/j.jaad.2023.04.069
DO - 10.1016/j.jaad.2023.04.069
M3 - Article
C2 - 37301288
AN - SCOPUS:85164307556
SN - 0190-9622
VL - 89
SP - 952
EP - 958
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -