On improving the speed and reliability of T2-relaxation-under- spin-tagging (TRUST) MRI

Feng Xu, Jinsoo Uh, Peiying Liu, Hanzhang Lu

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


A T2-relaxation-under-spin-tagging technique was recently developed to estimate cerebral blood oxygenation, providing potentials for noninvasive assessment of the brain's oxygen consumption. A limitation of the current sequence is the need for long repetition time, as shorter repetition time causes an over-estimation in blood R2. This study proposes a post-saturation T2-relaxation-under-spin-tagging by placing a non-selective 90° pulse after the signal acquisition to reset magnetization in the whole brain. This scheme was found to eliminate estimation bias at a slight cost of precision. To improve the precision, echo time of the sequence was optimized and it was found that a modest echo time shortening of 3.4 ms can reduce the estimation error by 49%. We recommend the use of postsaturation T2-relaxation-under-spin-tagging sequence with a repetition time of 3000 ms and a echo time of 3.6 ms, which allows the determination of global venous oxygenation with scan duration of 1 min 12 s and an estimation precision of ±1% (in units of oxygen saturation percentage).

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalMagnetic resonance in medicine
Issue number1
StatePublished - Jul 2012


  • Arterial spin labeling
  • Brain
  • Magnetization saturation
  • Noninvasive measurement
  • Oxygen saturation
  • Oxygenation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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