Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp

Du Yu Nie, Quan Hong Ma, Janice W S Law, Chern Pang Chia, Narender K. Dhingra, Yasushi Shimoda, Wu Lin Yang, Neng Gong, Qing Wen Chen, Gang Xu, Qi Dong Hu, Pierce K H Chow, Yee Kong Ng, Eng Ang Ling, Kazutada Watanabe, Tian Le Xu, Amyn A. Habib, Melitta Schachner, Zhi Cheng Xiao

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The molecular mechanisms underlying the involvement of oligodendrocytes in formation of the nodes of Ranvier (NORs) remain poorly understood. Here we show that oligodendrocyte-myelin glycoprotein (OMgp) aggregates specifically at NORs. Nodal location of OMgp does not occur along demyelinated axons of either Shiverer or proteolipid protein (PLP) transgenic mice. Over-expression of OMgp in OLN-93 cells facilitates process outgrowth. In transgenic mice in which expression of OMgp is down-regulated, myelin thickness declines, and lateral oligodendrocyte loops at the node-paranode junction are less compacted and even join together with the opposite loops, which leads to shortened nodal gaps. Notably, each of these structural abnormalities plus modest down-regulation of expression of Na+ channel α subunit result in reduced conduction velocity in the spinal cords of the mutant mice. Thus, OMgp that is derived from glia has distinct roles in regulating nodal formation and function during CNS myelination.

Original languageEnglish (US)
Pages (from-to)151-164
Number of pages14
JournalNeuron Glia Biology
Issue number3
StatePublished - Aug 2006


  • Myelination
  • Na channel
  • Node of Ranvier
  • OMgp
  • Oligodendrocyte

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


Dive into the research topics of 'Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp'. Together they form a unique fingerprint.

Cite this