Olfactory bulb axonal outgrowth is inhibited by draxin

Giasuddin Ahmed, Yohei Shinmyo, Iftekhar Bin Naser, Mahmud Hossain, Xiaohong Song, Hideaki Tanaka

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Olfactory bulb (OB) projection neurons receive sensory input from olfactory receptor neurons and precisely relay it through their axons to the olfactory cortex. Thus, olfactory bulb axonal tracts play an important role in relaying information to the higher order of olfactory structures in the brain. Several classes of axon guidance molecules influence the pathfinding of the olfactory bulb axons. Draxin, a recently identified novel class of repulsive axon guidance protein, is essential for the formation of forebrain commissures and can mediate repulsion of diverse classes of neurons from chickens and mice. In this study, we have investigated the draxin expression pattern in the mouse telencephalon and its guidance functions for OB axonal projection to the telencephalon. We have found that draxin is expressed in the neocortex and septum at E13 and E17.5 when OB projection neurons form the lateral olfactory tract (LOT) rostrocaudally along the ventrolateral side of the telencephalon. Draxin inhibits axonal outgrowth from olfactory bulb explants in vitro and draxin-binding activity in the LOT axons in vivo is detected. The LOT develops normally in draxin-/- mice despite subtle defasciculation in the tract of these mutants. These results suggest that draxin functions as an inhibitory guidance cue for OB axons and indicate its contribution to the formation of the LOT.

Original languageEnglish (US)
Pages (from-to)730-734
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Aug 2010
Externally publishedYes


  • Axonal outgrowth
  • Draxin
  • LOT
  • Olfactory bulb
  • Repulsive guidance cue

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Olfactory bulb axonal outgrowth is inhibited by draxin'. Together they form a unique fingerprint.

Cite this