Obesity is associated with better survival and functional outcome after acute intracerebral hemorrhage

Weiping Sun, Ying Xian, Yining Huang, Wei Sun, Ran Liu, Fan Li, Jade W. Wei, Ji Guang Wang, Ming Liu, Yangfeng Wu, Lawrence K.S. Wong, Craig S. Anderson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH). Methods Data were from 1571 patients with ICH enrolled in a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. The outcomes included all-cause mortality at 12 months, and death or high dependency at 3 and 12 months. High dependency was defined as a modified Rankin Scale score of 3–5. Results Of 1571 patients with ICH, 109 were underweight (BMI < 18.5 kg/m2), 657 were normal-weight (BMI 18.5–23 kg/m2), 341 were overweight (BMI 23–25 kg/m2) and 464 were obese (BMI ≥ 25 kg/m2). Compared with normal-weight patients, obese patients had significantly decreased risks of death at 12 months (HR: 0.71, 95% CI: 0.56–0.91) and death or high dependency at 3 and 12 months (OR: 0.71, 95% CI: 0.53–0.95; OR: 0.69, 95% CI: 0.51–0.94) after adjusting for baseline characteristics. Neither underweight nor overweight was associated with these three outcomes significantly. Conclusions In patients with acute ICH, being obese is associated with a decreased mortality and better functional recovery. Further interventional studies are needed to guide the weight management strategy for patients with ICH.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalJournal of the Neurological Sciences
StatePublished - Nov 15 2016
Externally publishedYes


  • Dependency
  • Intracerebral hemorrhage
  • Mortality
  • Obesity
  • Outcome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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