Numb and Numblike control cell number during vertebrate neurogenesis

Jane E. Johnson

doi:10.1016/S0166-2236(03)00166-8

Numb and Numblike control cell number during vertebrate neurogenesis

Jane E. Johnson

Research output: Contribution to journal › Short survey › peer-review

31 Scopus citations

Abstract

A fundamental problem in nervous system development is how to control progenitor-cell divisions to generate the correct number of cells for the mature brain and spinal cord. A recent report by Petersen and colleagues has identified an essential role for Numb and a related protein, Numblike, in this process. This study demonstrates that Numb and Numblike function to maintain the self-renewal properties of neural progenitor cells in the vertebrate neural tube.

Original language	English (US)
Pages (from-to)	395-396
Number of pages	2
Journal	Trends in Neurosciences
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/S0166-2236(03)00166-8
State	Published - Aug 1 2003

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0166-2236(03)00166-8

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abstract = "A fundamental problem in nervous system development is how to control progenitor-cell divisions to generate the correct number of cells for the mature brain and spinal cord. A recent report by Petersen and colleagues has identified an essential role for Numb and a related protein, Numblike, in this process. This study demonstrates that Numb and Numblike function to maintain the self-renewal properties of neural progenitor cells in the vertebrate neural tube.",

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AB - A fundamental problem in nervous system development is how to control progenitor-cell divisions to generate the correct number of cells for the mature brain and spinal cord. A recent report by Petersen and colleagues has identified an essential role for Numb and a related protein, Numblike, in this process. This study demonstrates that Numb and Numblike function to maintain the self-renewal properties of neural progenitor cells in the vertebrate neural tube.

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Numb and Numblike control cell number during vertebrate neurogenesis

Abstract

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