TY - JOUR
T1 - Nuclear receptors, coactivators and chromatin
T2 - New approaches, new insights
AU - Lee, Kathleen C.
AU - Kraus, W. Lee
PY - 2001
Y1 - 2001
N2 - The actions of lipophilic hormones, including steroids, retinoids, thyroid hormone and vitamin D3, are mediated through a conserved superfamily of nuclear receptor proteins that function as ligand-regulated, DNA-binding transcriptional activators in the chromatin environment of the nucleus. The ligand-dependent transcriptional activity of nuclear receptors is enhanced by various cofactors that remodel chromatin, acetylate nucleosomal histones and contact the basal transcriptional machinery. The current challenge is to understand the mechanistic details of how interactions among these factors enhance transcription of hormone-regulated genes assembled into chromatin. Current biochemical and cell-based methods are providing some important clues.
AB - The actions of lipophilic hormones, including steroids, retinoids, thyroid hormone and vitamin D3, are mediated through a conserved superfamily of nuclear receptor proteins that function as ligand-regulated, DNA-binding transcriptional activators in the chromatin environment of the nucleus. The ligand-dependent transcriptional activity of nuclear receptors is enhanced by various cofactors that remodel chromatin, acetylate nucleosomal histones and contact the basal transcriptional machinery. The current challenge is to understand the mechanistic details of how interactions among these factors enhance transcription of hormone-regulated genes assembled into chromatin. Current biochemical and cell-based methods are providing some important clues.
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U2 - 10.1016/S1043-2760(01)00392-7
DO - 10.1016/S1043-2760(01)00392-7
M3 - Review article
C2 - 11397643
AN - SCOPUS:0035405737
SN - 1043-2760
VL - 12
SP - 191
EP - 197
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 5
ER -