TY - JOUR
T1 - Nuclear receptors and cholesterol metabolism in the intestine
AU - Moschetta, Antonio
N1 - Funding Information:
This work was funded by an unrestricted grant by MSD Italia Srl. The sponsor had no role in reviewing the literature, drafting or reviewing the paper, or in the decision to submit the manuscript for publication. All views expressed are solely those of the author. The author would like to thank Editamed Srl for editorial assistance in the preparation of the manuscript.
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Nuclear receptors are involved in many important function and mediate signaling by factors including hormones, vitamins and a number of endogenous ligands and xenobiotics, several of which are involved in lipid metabolism. This review focuses on the liver X receptor (LXR), which is an important regulator of whole-body cholesterol, fatty acid, and glucose homeostasis that binds to LXR response elements as a heterodimer with retinoid X receptors, and the farnesoid X receptor (FXR), which is a bile acid receptor involved in feedback inhibition of bile acid synthesis, and thus cholesterol catabolism. These nuclear receptors regulate gene programs that control intestinal and hepatic lipid homeostasis through their effects on cholesterol transport and catabolism.
AB - Nuclear receptors are involved in many important function and mediate signaling by factors including hormones, vitamins and a number of endogenous ligands and xenobiotics, several of which are involved in lipid metabolism. This review focuses on the liver X receptor (LXR), which is an important regulator of whole-body cholesterol, fatty acid, and glucose homeostasis that binds to LXR response elements as a heterodimer with retinoid X receptors, and the farnesoid X receptor (FXR), which is a bile acid receptor involved in feedback inhibition of bile acid synthesis, and thus cholesterol catabolism. These nuclear receptors regulate gene programs that control intestinal and hepatic lipid homeostasis through their effects on cholesterol transport and catabolism.
KW - Bile acid
KW - Cholesterol
KW - Farnesoid X receptor
KW - Fibroblast growth factor-19
KW - Lipid metabolism
KW - Liver X receptor
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U2 - 10.1016/S1567-5688(15)50003-2
DO - 10.1016/S1567-5688(15)50003-2
M3 - Article
C2 - 25659870
AN - SCOPUS:84924964360
SN - 1567-5688
VL - 17
SP - 9
EP - 11
JO - Atherosclerosis Supplements
JF - Atherosclerosis Supplements
ER -