TY - JOUR
T1 - NSAID gastrointestinal toxicity
AU - Cryer, B.
PY - 2000/12/1
Y1 - 2000/12/1
N2 - Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal antiinflammatory drugs (NSAIDs). During the last several years there have been several advances, both in the laboratory and clinically, toward reducing NSAIDs' gastrointestinal toxicity. Some of these important developments have been the delineation of mechanisms of NSAID-induced GI toxicity, identification of groups at highest risk for development of NSAID-induced gastrointestinal complications, recognition of cotherapies that could reduce NSAID toxicity, and, most recently, development of classes of NSAIDs that have an improved gastrointestinal safety profile. Many of these advances occurred during the last year. This review focuses on several of the important recent observations that have improved our understanding and the safety of NSAIDs in the gastrointestinal tract.
AB - Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal antiinflammatory drugs (NSAIDs). During the last several years there have been several advances, both in the laboratory and clinically, toward reducing NSAIDs' gastrointestinal toxicity. Some of these important developments have been the delineation of mechanisms of NSAID-induced GI toxicity, identification of groups at highest risk for development of NSAID-induced gastrointestinal complications, recognition of cotherapies that could reduce NSAID toxicity, and, most recently, development of classes of NSAIDs that have an improved gastrointestinal safety profile. Many of these advances occurred during the last year. This review focuses on several of the important recent observations that have improved our understanding and the safety of NSAIDs in the gastrointestinal tract.
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U2 - 10.1097/00001574-200011000-00006
DO - 10.1097/00001574-200011000-00006
M3 - Review article
C2 - 17031127
AN - SCOPUS:0034438775
SN - 0267-1379
VL - 16
SP - 495
EP - 502
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 6
ER -