TY - JOUR
T1 - NSAID-associated deaths
T2 - The rise and fall of NSAID-associated GI mortality
AU - Cryer, Byron
PY - 2005/8
Y1 - 2005/8
N2 - Although gastrointestinal (GI) morbidity and mortality from NSAIDs continues to be a significant problem, this study by Lanas et al. Indicates that the magnitude of the concern is declining. Explanations for this reduction are more likely related to the increased use of proton pump inhibitors (PPIs) than to the introduction of COX-2 inhibitors. This study further reveals that one-third of NSAIDs' GI mortality comes from low-dose, daily aspirin. Another important contribution derived from this report is a more reliable estimate of NSAIDs' lower GI clinical consequences than previously available.
AB - Although gastrointestinal (GI) morbidity and mortality from NSAIDs continues to be a significant problem, this study by Lanas et al. Indicates that the magnitude of the concern is declining. Explanations for this reduction are more likely related to the increased use of proton pump inhibitors (PPIs) than to the introduction of COX-2 inhibitors. This study further reveals that one-third of NSAIDs' GI mortality comes from low-dose, daily aspirin. Another important contribution derived from this report is a more reliable estimate of NSAIDs' lower GI clinical consequences than previously available.
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U2 - 10.1111/j.1572-0241.2005.50565.x
DO - 10.1111/j.1572-0241.2005.50565.x
M3 - Review article
C2 - 16144121
AN - SCOPUS:25644460012
SN - 0002-9270
VL - 100
SP - 1694
EP - 1695
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -