NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation

Takashi Yasukawa; Aya Tsutsui; Chieri Tomomori-Sato; Shigeo Sato; Anita Saraf; Michael P. Washburn; Laurence Florens; Tohru Terada; Kentaro Shimizu; Ronald C. Conaway; Joan W. Conaway; Teijiro Aso

doi:10.1016/j.celrep.2020.02.059

NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation

Takashi Yasukawa, Aya Tsutsui, Chieri Tomomori-Sato, Shigeo Sato, Anita Saraf, Michael P. Washburn, Laurence Florens, Tohru Terada, Kentaro Shimizu, Ronald C. Conaway, Joan W. Conaway, Teijiro Aso

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Yasukawa et al. demonstrate that BRI2 and BRI3, physiological inhibitors of Aβ production and aggregation, are substrates of NRBP1-ubiquitin ligase. In the presence of TSC22D3 and TSC22D4, a dimer of the substrate receptor NRBP1 assembles into a functional Cul2- and Cul4A-containing heterodimeric CRL through overlapping BC-box and cryptic H-box motifs on NRBP1.

Original language	English (US)
Pages (from-to)	3478-3491.e6
Journal	Cell Reports
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.02.059
State	Published - Mar 10 2020
Externally published	Yes

Keywords

Alzheimer's disease
BRI2/ITM2B
BRI3/ITM2C
CRL
Cullin
E3 ubiquitin ligase
NRBP1
amyloid β
amyloid-β precursor protein/APP
ubiquitination

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.02.059

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title = "NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation",

abstract = "Yasukawa et al. demonstrate that BRI2 and BRI3, physiological inhibitors of Aβ production and aggregation, are substrates of NRBP1-ubiquitin ligase. In the presence of TSC22D3 and TSC22D4, a dimer of the substrate receptor NRBP1 assembles into a functional Cul2- and Cul4A-containing heterodimeric CRL through overlapping BC-box and cryptic H-box motifs on NRBP1.",

keywords = "Alzheimer's disease, BRI2/ITM2B, BRI3/ITM2C, CRL, Cullin, E3 ubiquitin ligase, NRBP1, amyloid β, amyloid-β precursor protein/APP, ubiquitination",

author = "Takashi Yasukawa and Aya Tsutsui and Chieri Tomomori-Sato and Shigeo Sato and Anita Saraf and Washburn, {Michael P.} and Laurence Florens and Tohru Terada and Kentaro Shimizu and Conaway, {Ronald C.} and Conaway, {Joan W.} and Teijiro Aso",

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year = "2020",

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doi = "10.1016/j.celrep.2020.02.059",

language = "English (US)",

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T1 - NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation

AU - Yasukawa, Takashi

AU - Tsutsui, Aya

AU - Tomomori-Sato, Chieri

AU - Sato, Shigeo

AU - Saraf, Anita

AU - Washburn, Michael P.

AU - Florens, Laurence

AU - Terada, Tohru

AU - Shimizu, Kentaro

AU - Conaway, Ronald C.

AU - Conaway, Joan W.

AU - Aso, Teijiro

PY - 2020/3/10

Y1 - 2020/3/10

N2 - Yasukawa et al. demonstrate that BRI2 and BRI3, physiological inhibitors of Aβ production and aggregation, are substrates of NRBP1-ubiquitin ligase. In the presence of TSC22D3 and TSC22D4, a dimer of the substrate receptor NRBP1 assembles into a functional Cul2- and Cul4A-containing heterodimeric CRL through overlapping BC-box and cryptic H-box motifs on NRBP1.

AB - Yasukawa et al. demonstrate that BRI2 and BRI3, physiological inhibitors of Aβ production and aggregation, are substrates of NRBP1-ubiquitin ligase. In the presence of TSC22D3 and TSC22D4, a dimer of the substrate receptor NRBP1 assembles into a functional Cul2- and Cul4A-containing heterodimeric CRL through overlapping BC-box and cryptic H-box motifs on NRBP1.

KW - Alzheimer's disease

KW - BRI2/ITM2B

KW - BRI3/ITM2C

KW - CRL

KW - Cullin

KW - E3 ubiquitin ligase

KW - NRBP1

KW - amyloid β

KW - amyloid-β precursor protein/APP

KW - ubiquitination

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U2 - 10.1016/j.celrep.2020.02.059

DO - 10.1016/j.celrep.2020.02.059

M3 - Article

C2 - 32160551

AN - SCOPUS:85081022015

SN - 2211-1247

VL - 30

SP - 3478-3491.e6

JO - Cell Reports

JF - Cell Reports

IS - 10

ER -

NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation

Abstract

Keywords

ASJC Scopus subject areas

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