Yasukawa et al. demonstrate that BRI2 and BRI3, physiological inhibitors of Aβ production and aggregation, are substrates of NRBP1-ubiquitin ligase. In the presence of TSC22D3 and TSC22D4, a dimer of the substrate receptor NRBP1 assembles into a functional Cul2- and Cul4A-containing heterodimeric CRL through overlapping BC-box and cryptic H-box motifs on NRBP1.
- Alzheimer's disease
- amyloid β
- amyloid-β precursor protein/APP
- E3 ubiquitin ligase
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)