Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

Joachim Wittbrodt; Dieter Adam; Barbara Malitschek; Winfried Mäueler; Friedrich Raulf; Agnes Telling; Scott M. Robertson; Manfred Schartl

doi:10.1038/341415a0

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

Joachim Wittbrodt, Dieter Adam, Barbara Malitschek, Winfried Mäueler, Friedrich Raulf, Agnes Telling, Scott M. Robertson, Manfred Schartl

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278 Scopus citations

Abstract

Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

Original language	English (US)
Pages (from-to)	415-421
Number of pages	7
Journal	Nature
Volume	341
Issue number	6241
DOIs	https://doi.org/10.1038/341415a0
State	Published - 1989

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title = "Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus",

abstract = "Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.",

author = "Joachim Wittbrodt and Dieter Adam and Barbara Malitschek and Winfried M{\"a}ueler and Friedrich Raulf and Agnes Telling and Robertson, {Scott M.} and Manfred Schartl",

year = "1989",

doi = "10.1038/341415a0",

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pages = "415--421",

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T1 - Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

AU - Wittbrodt, Joachim

AU - Adam, Dieter

AU - Malitschek, Barbara

AU - Mäueler, Winfried

AU - Raulf, Friedrich

AU - Telling, Agnes

AU - Robertson, Scott M.

AU - Schartl, Manfred

PY - 1989

Y1 - 1989

N2 - Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

AB - Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene codes for a novel receptor tyrosine kinase which is closely related to the receptor for epidermal growth factor.

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U2 - 10.1038/341415a0

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JO - Nature

JF - Nature

IS - 6241

ER -

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

Abstract

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