Novel Online PET Imaging for Intrabeam Range Verification and Delivery Optimization: A Simulation Feasibility Study

Yuncheng Zhong, Weiguo Lu, Mingli Chen, Zhenyu Xiong, Xinyi Cheng, Kun Hu, Yiping Shao

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Online positron emission tomography (PET) image-based method uses an initial particle beam to measure the particle beam range (BR) within the same fraction so that any measured range-shift with respect to the predicted BR can be compensated before the rest therapeutic beam deliveries. However, the method requires to use a low-dose initial beam to minimize the risk of beam overshooting, which leads to low image count and inaccurate BR measurement. In this in-silico study, we evaluate the feasibility of a new online PET imaging method that measures BR at the mid-plane of a target volume with part of the high-dose therapy beams to verify BR and guide adaptive treatment replanning. Simulations included various processes of proton beam radiations to a tumor inside a human-brain phantom, positron, and PET image generation at the mid-plane with initial beams, activity range measurement, and range-shift compensated beam delivery. The results demonstrated that the new method, under the simulated conditions, can achieve 1.1-mm mid-plane BR measurement accuracy and closely match the delivered range-shift compensated dose distribution with the planned one. Overall, it is promising that this new method may significantly improve the particle therapy accuracy.

Original languageEnglish (US)
Article number8887266
Pages (from-to)212-217
Number of pages6
JournalIEEE Transactions on Radiation and Plasma Medical Sciences
Issue number2
StatePublished - Mar 2020


  • Beam range (BR) verification
  • online positron emission tomography (PET) imaging
  • particle beam therapy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Radiology Nuclear Medicine and imaging


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