TY - JOUR
T1 - Novel mechanisms of microbial crosstalk with skin innate immunity
AU - Chinnappan, Mahendran
AU - Harris-Tryon, Tamia A.
N1 - Funding Information:
The figures used in this manuscript were created using Biorender.com. T.A.H. is supported by the National Institutes of Health‐K08 AR076459‐01, a Harold Amos Award through the Robert Wood Johnson Foundation, a UT Southwestern Disease Oriented Clinical Scholars Program award, and a Burroughs Wellcome Fund Career Award for Medical Scientists.
Funding Information:
The figures used in this manuscript were created using Biorender.com. T.A.H. is supported by the National Institutes of Health-K08 AR076459-01, a Harold Amos Award through the Robert Wood Johnson Foundation, a UT Southwestern Disease Oriented Clinical Scholars Program award, and a Burroughs Wellcome Fund Career Award for Medical Scientists.
Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2021/10
Y1 - 2021/10
N2 - Skin is an organ with a dynamic ecosystem that harbours pathogenic and commensal microbes, which constantly communicate amongst each other and with the host immune system. Evolutionarily, skin and its microbiota have evolved to remain in homeostasis. However, frequently this homeostatic relationship is disturbed by a variety of factors such as environmental stress, diet, genetic mutations, and the microbiome itself. Commensal microbes also play a major role in the maintenance of microbial homeostasis. In addition to their ability to limit pathogens, many skin commensals such as Staphylococcus epidermidis and Cutibacterium acnes have recently been implicated in disease pathogenesis either by directly modulating the host immune components or by supporting the expansion of other pathogenic microbes. Likewise, opportunistic skin pathogens such as Staphylococcus aureus and Staphylococcus lugdunensis are able to breach the skin and cause disease. Though much has been established about the microbiota's function in skin immunity, we are in a time where newer mechanistic insights rapidly redefine our understanding of the host/microbial interface in the skin. In this review, we provide a concise summary of recent advances in our understanding of the interplay between host defense strategies and the skin microbiota.
AB - Skin is an organ with a dynamic ecosystem that harbours pathogenic and commensal microbes, which constantly communicate amongst each other and with the host immune system. Evolutionarily, skin and its microbiota have evolved to remain in homeostasis. However, frequently this homeostatic relationship is disturbed by a variety of factors such as environmental stress, diet, genetic mutations, and the microbiome itself. Commensal microbes also play a major role in the maintenance of microbial homeostasis. In addition to their ability to limit pathogens, many skin commensals such as Staphylococcus epidermidis and Cutibacterium acnes have recently been implicated in disease pathogenesis either by directly modulating the host immune components or by supporting the expansion of other pathogenic microbes. Likewise, opportunistic skin pathogens such as Staphylococcus aureus and Staphylococcus lugdunensis are able to breach the skin and cause disease. Though much has been established about the microbiota's function in skin immunity, we are in a time where newer mechanistic insights rapidly redefine our understanding of the host/microbial interface in the skin. In this review, we provide a concise summary of recent advances in our understanding of the interplay between host defense strategies and the skin microbiota.
KW - Staphylococcus aureus
KW - antimicrobials
KW - atopic dermatitis
KW - commensal
KW - microbiome
KW - microbiota
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U2 - 10.1111/exd.14429
DO - 10.1111/exd.14429
M3 - Review article
C2 - 34252227
AN - SCOPUS:85110958792
SN - 0906-6705
VL - 30
SP - 1484
EP - 1495
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 10
ER -