TY - JOUR
T1 - Novel markers predict death and organ failure following hemorrhagic shock
AU - Furmaga, Wieslaw
AU - Cohn, Stephen
AU - Prihoda, Thomas J.
AU - Mikhailov, Valery
AU - McCarthy, Janet
AU - Arar, Yousef
N1 - Funding Information:
We thank for Dr. Robber Reddick, the Chairman of Department of Pathology at UTHSC at San Antonio for financial supporting of entire project and Dr. Philip LoVerde for his data analyzing and contribution to paper writing and correction. This study was supported by the Office of Naval Research (Grant: W81XWH-08-1-0013 ) and the Departments of Pathology and Surgery, UTHSCSA .
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/2/2
Y1 - 2015/2/2
N2 - Background: ADAMTS 13, sP-Selectin and HSP27 have been investigated as potential prognostic markers in patients with hemorrhagic shock. Methods: This study was part of a double-blind, randomized, parallel-group, controlled trial and included seventeen trauma patients presented to ED with severe hemorrhagic. The sera for testing were collected from these patients at the time of admission. Investigators and laboratory personnel performing testing were blinded to the patients' identity and clinical course. Results: The prognostic value of ADAMTS13, sP-Selectin, and HSP27 was compared to prognostic value of systolic blood pressure (SBP), base deficit estimation (BD), heart rate (HR), shock index (SI) and tissue oxygen saturation (StO2) by constructing the receiver operation characteristics (ROC). The area under the curve (AUC) of the ROC for HSP27 (0.92) was greater than for SBP (0.45), BD (0.89), HR (0.61), SI (0.45) and StO2 (0.46). AUC for sP-Selectin (0.86) and for ADAMTS13 antigen (0.74) were comparable with BD one, but greater than for the rest of currently used tests. Conclusion: Serum concentrations of ADAMTS13, HSP27 and sP-Selectin measured during the admission, appear to be comparable to or better than SBP, BD, SI, HR and StO2 in predicting MODS and death after hemorrhage from trauma. These potential new markers deserve further investigation.
AB - Background: ADAMTS 13, sP-Selectin and HSP27 have been investigated as potential prognostic markers in patients with hemorrhagic shock. Methods: This study was part of a double-blind, randomized, parallel-group, controlled trial and included seventeen trauma patients presented to ED with severe hemorrhagic. The sera for testing were collected from these patients at the time of admission. Investigators and laboratory personnel performing testing were blinded to the patients' identity and clinical course. Results: The prognostic value of ADAMTS13, sP-Selectin, and HSP27 was compared to prognostic value of systolic blood pressure (SBP), base deficit estimation (BD), heart rate (HR), shock index (SI) and tissue oxygen saturation (StO2) by constructing the receiver operation characteristics (ROC). The area under the curve (AUC) of the ROC for HSP27 (0.92) was greater than for SBP (0.45), BD (0.89), HR (0.61), SI (0.45) and StO2 (0.46). AUC for sP-Selectin (0.86) and for ADAMTS13 antigen (0.74) were comparable with BD one, but greater than for the rest of currently used tests. Conclusion: Serum concentrations of ADAMTS13, HSP27 and sP-Selectin measured during the admission, appear to be comparable to or better than SBP, BD, SI, HR and StO2 in predicting MODS and death after hemorrhage from trauma. These potential new markers deserve further investigation.
KW - ADAMTS13
KW - HSP27
KW - Hemorrhagic shock
KW - Hemorrhagic shock markers
KW - Multi-organ failure
KW - SP-Selectin
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U2 - 10.1016/j.cca.2014.10.045
DO - 10.1016/j.cca.2014.10.045
M3 - Article
C2 - 25444751
AN - SCOPUS:84912567723
SN - 0009-8981
VL - 440
SP - 87
EP - 92
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -